pIRESneo-FLAG/HA Ago2 corrected Citations (51)
Originally described in: Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T Mol Cell. 2004 Jul 23. 15(2):185-97. PubMed Journal
Articles Citing pIRESneo-FLAG/HA Ago2 corrected
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| Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Buchet-Poyau K, Courchet J, Le Hir H, Seraphin B, Scoazec JY, Duret L, Domon-Dell C, Freund JN, Billaud M. Nucleic Acids Res. 2007;35(4):1289-300. Epub 2007 Jan 31. PubMed |
| Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies. Savas JN, Makusky A, Ottosen S, Baillat D, Then F, Krainc D, Shiekhattar R, Markey SP, Tanese N. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10820-5. doi: 10.1073/pnas.0800658105. Epub 2008 Jul 31. PubMed |
| The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G. Suzuki Y, Minami M, Suzuki M, Abe K, Zenno S, Tsujimoto M, Matsumoto K, Minami Y. J Biol Chem. 2009 Dec 18;284(51):35597-604. doi: 10.1074/jbc.M109.036285. Epub . PubMed |
| Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter. Chu Y, Yue X, Younger ST, Janowski BA, Corey DR. Nucleic Acids Res. 2010 Nov;38(21):7736-48. doi: 10.1093/nar/gkq648. Epub 2010 Jul 30. PubMed |
| Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver. Grimm D, Wang L, Lee JS, Schurmann N, Gu S, Borner K, Storm TA, Kay MA. J Clin Invest. 2010 Sep;120(9):3106-19. doi: 10.1172/JCI43565. Epub 2010 Aug 9. PubMed |
| Ebolavirus proteins suppress the effects of small interfering RNA by direct interaction with the mammalian RNA interference pathway. Fabozzi G, Nabel CS, Dolan MA, Sullivan NJ. J Virol. 2011 Mar;85(6):2512-23. doi: 10.1128/JVI.01160-10. Epub 2011 Jan 12. PubMed |
| Molecular characterization of the microRNA-138-Fos-like antigen 1 (FOSL1) regulatory module in squamous cell carcinoma. Jin Y, Wang C, Liu X, Mu W, Chen Z, Yu D, Wang A, Dai Y, Zhou X. J Biol Chem. 2011 Nov 18;286(46):40104-9. doi: 10.1074/jbc.C111.296707. Epub 2011 Oct 3. PubMed |
| Upregulation of Cyclin B1 by miRNA and its implications in cancer. Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J, Li LC. Nucleic Acids Res. 2012 Feb;40(4):1695-707. doi: 10.1093/nar/gkr934. Epub 2011 Nov 3. PubMed |
| Expression determinants of mammalian argonaute proteins in mediating gene silencing. Valdmanis PN, Gu S, Schuermann N, Sethupathy P, Grimm D, Kay MA. Nucleic Acids Res. 2012 Apr;40(8):3704-13. doi: 10.1093/nar/gkr1274. Epub 2011 Dec 30. PubMed |
Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins.
Janas MM, Wang B, Harris AS, Aguiar M, Shaffer JM, Subrahmanyam YV, Behlke MA, Wucherpfennig KW, Gygi SP, Gagnon E, Novina CD.
RNA. 2012 Nov;18(11):2041-55. doi: 10.1261/rna.035675.112. Epub 2012 Sep 27.
PubMed
Associated Plasmids |
| Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. Martinez NJ, Gregory RI. RNA. 2013 May;19(5):605-12. doi: 10.1261/rna.036434.112. Epub 2013 Mar 13. PubMed |
| MicroRNA-99 family targets AKT/mTOR signaling pathway in dermal wound healing. Jin Y, Tymen SD, Chen D, Fang ZJ, Zhao Y, Dragas D, Dai Y, Marucha PT, Zhou X. PLoS One. 2013 May 28;8(5):e64434. doi: 10.1371/journal.pone.0064434. Print 2013. PubMed |
| Molecular dissection of human Argonaute proteins by DNA shuffling. Schurmann N, Trabuco LG, Bender C, Russell RB, Grimm D. Nat Struct Mol Biol. 2013 Jul;20(7):818-26. doi: 10.1038/nsmb.2607. Epub 2013 Jun 9. PubMed |
| The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA. Geissler V, Altmeyer S, Stein B, Uhlmann-Schiffler H, Stahl H. Nucleic Acids Res. 2013 Sep;41(16):7875-88. doi: 10.1093/nar/gkt538. Epub 2013 Jun 20. PubMed |
| Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines. Borner K, Niopek D, Cotugno G, Kaldenbach M, Pankert T, Willemsen J, Zhang X, Schurmann N, Mockenhaupt S, Serva A, Hiet MS, Wiedtke E, Castoldi M, Starkuviene V, Erfle H, Gilbert DF, Bartenschlager R, Boutros M, Binder M, Streetz K, Krausslich HG, Grimm D. Nucleic Acids Res. 2013 Nov;41(21):e199. doi: 10.1093/nar/gkt836. Epub 2013 Sep 17. PubMed |
| The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly. Martinez NJ, Chang HM, Borrajo Jde R, Gregory RI. RNA. 2013 Nov;19(11):1583-93. doi: 10.1261/rna.040790.113. Epub 2013 Sep 18. PubMed |
| Ago1 Interacts with RNA polymerase II and binds to the promoters of actively transcribed genes in human cancer cells. Huang V, Zheng J, Qi Z, Wang J, Place RF, Yu J, Li H, Li LC. PLoS Genet. 2013;9(9):e1003821. doi: 10.1371/journal.pgen.1003821. Epub 2013 Sep 26. PubMed |
| RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells. Ciaudo C, Jay F, Okamoto I, Chen CJ, Sarazin A, Servant N, Barillot E, Heard E, Voinnet O. PLoS Genet. 2013 Nov;9(11):e1003791. doi: 10.1371/journal.pgen.1003791. Epub 2013 Nov 7. PubMed |
| MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells. Chen D, Chen Z, Jin Y, Dragas D, Zhang L, Adjei BS, Wang A, Dai Y, Zhou X. PLoS One. 2013 Dec 3;8(12):e80625. doi: 10.1371/journal.pone.0080625. eCollection 2013. PubMed |
| Regulation of microRNA-mediated gene silencing by microRNA precursors. Roy-Chaudhuri B, Valdmanis PN, Zhang Y, Wang Q, Luo QJ, Kay MA. Nat Struct Mol Biol. 2014 Sep;21(9):825-32. doi: 10.1038/nsmb.2862. Epub 2014 Aug 3. PubMed |
| Potent degradation of neuronal miRNAs induced by highly complementary targets. de la Mata M, Gaidatzis D, Vitanescu M, Stadler MB, Wentzel C, Scheiffele P, Filipowicz W, Grosshans H. EMBO Rep. 2015 Apr;16(4):500-11. doi: 10.15252/embr.201540078. Epub 2015 Feb 27. PubMed |
| miR-5100 promotes tumor growth in lung cancer by targeting Rab6. Huang H, Jiang Y, Wang Y, Chen T, Yang L, He H, Lin Z, Liu T, Yang T, Kamp DW, Wu B, Liu G. Cancer Lett. 2015 Jun 28;362(1):15-24. doi: 10.1016/j.canlet.2015.03.004. Epub 2015 Mar 6. PubMed |
| MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation. Jiang J, Zhang Y, Guo Y, Yu C, Chen M, Li Z, Tian S, Sun C. Oncotarget. 2015 Mar 20;6(8):6359-72. PubMed |
| eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference. Yi T, Arthanari H, Akabayov B, Song H, Papadopoulos E, Qi HH, Jedrychowski M, Guttler T, Guo C, Luna RE, Gygi SP, Huang SA, Wagner G. Nat Commun. 2015 May 28;6:7194. doi: 10.1038/ncomms8194. PubMed |
| The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication. Ingle H, Kumar S, Raut AA, Mishra A, Kulkarni DD, Kameyama T, Takaoka A, Akira S, Kumar H. Sci Signal. 2015 Dec 8;8(406):ra126. doi: 10.1126/scisignal.aab3183. PubMed |
| MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/beta-catenin signaling in breast cancer. Tan Z, Zheng H, Liu X, Zhang W, Zhu J, Wu G, Cao L, Song J, Wu S, Song L, Li J. Oncotarget. 2016 Apr 26;7(17):24076-87. doi: 10.18632/oncotarget.8119. PubMed |
miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage.
Salzman DW, Nakamura K, Nallur S, Dookwah MT, Metheetrairut C, Slack FJ, Weidhaas JB.
Nat Commun. 2016 Mar 21;7:10954. doi: 10.1038/ncomms10954.
PubMed
Associated Plasmids |
| MicroRNA-338 Attenuates Cortical Neuronal Outgrowth by Modulating the Expression of Axon Guidance Genes. Kos A, Klein-Gunnewiek T, Meinhardt J, Loohuis NF, van Bokhoven H, Kaplan BB, Martens GJ, Kolk SM, Aschrafi A. Mol Neurobiol. 2016 May 14. PubMed |
| Stable association of RNAi machinery is conserved between the cytoplasm and nucleus of human cells. Kalantari R, Hicks JA, Li L, Gagnon KT, Sridhara V, Lemoff A, Mirzaei H, Corey DR. RNA. 2016 Jul;22(7):1085-98. doi: 10.1261/rna.056499.116. Epub 2016 May 19. PubMed |
| MiR-760 overexpression promotes proliferation in ovarian cancer by downregulation of PHLPP2 expression. Liao Y, Deng Y, Liu J, Ye Z, You Z, Yao S, He S. Gynecol Oncol. 2016 Dec;143(3):655-663. doi: 10.1016/j.ygyno.2016.09.010. Epub 2016 Oct 7. PubMed |
| Induction and suppression of antiviral RNA interference by influenza A virus in mammalian cells. Li Y, Basavappa M, Lu J, Dong S, Cronkite DA, Prior JT, Reinecker HC, Hertzog P, Han Y, Li WX, Cheloufi S, Karginov FV, Ding SW, Jeffrey KL. Nat Microbiol. 2016 Dec 5;2:16250. doi: 10.1038/nmicrobiol.2016.250. PubMed |
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing.
Golden RJ, Chen B, Li T, Braun J, Manjunath H, Chen X, Wu J, Schmid V, Chang TC, Kopp F, Ramirez-Martinez A, Tagliabracci VS, Chen ZJ, Xie Y, Mendell JT.
Nature. 2017 Feb 9;542(7640):197-202. doi: 10.1038/nature21025. Epub 2017 Jan 23.
PubMed
Associated Plasmids |
| miR150 inhibits proliferation and tumorigenicity via retarding G1/S phase transition in nasopharyngeal carcinoma. Li X, Liu F, Lin B, Luo H, Liu M, Wu J, Li C, Li R, Zhang X, Zhou K, Ren D. Int J Oncol. 2017 Mar 10. doi: 10.3892/ijo.2017.3909. PubMed |
| Analysis of AgoshRNA maturation and loading into Ago2. Harwig A, Kruize Z, Yang Z, Restle T, Berkhout B. PLoS One. 2017 Aug 15;12(8):e0183269. doi: 10.1371/journal.pone.0183269. eCollection 2017. PubMed |
| Downregulation of miR19a3p promotes invasion, migration and bone metastasis via activating TGFbeta signaling in prostate cancer. Wa Q, Li L, Lin H, Peng X, Ren D, Huang Y, He P, Huang S. Oncol Rep. 2018 Jan;39(1):81-90. doi: 10.3892/or.2017.6096. Epub 2017 Nov 13. PubMed |
| The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells. van der Veen AG, Maillard PV, Schmidt JM, Lee SA, Deddouche-Grass S, Borg A, Kjaer S, Snijders AP, Reis E Sousa C. EMBO J. 2018 Feb 15;37(4). pii: embj.201797479. doi: 10.15252/embj.201797479. Epub 2018 Jan 19. PubMed |
| miR1495p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway. Xu M, Xiao J, Chen M, Yuan L, Li J, Shen H, Yao S. Int J Oncol. 2018 Mar;52(3):815-827. doi: 10.3892/ijo.2018.4252. Epub 2018 Jan 24. PubMed |
| Downregulation of miR-374b-5p promotes chemotherapeutic resistance in pancreatic cancer by upregulating multiple anti-apoptotic proteins. Sun D, Wang X, Sui G, Chen S, Yu M, Zhang P. Int J Oncol. 2018 Mar 14. doi: 10.3892/ijo.2018.4315. PubMed |
| Differences in silencing of mismatched targets by sliced versus diced siRNAs. Sun G, Wang J, Huang Y, Yuan CW, Zhang K, Hu S, Chen L, Lin RJ, Yen Y, Riggs AD. Nucleic Acids Res. 2018 Jul 27;46(13):6806-6822. doi: 10.1093/nar/gky287. PubMed |
| MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2. Kumar A, Kumar A, Ingle H, Kumar S, Mishra R, Verma MK, Biswas D, Kumar NS, Mishra A, Raut AA, Takaoka A, Kumar H. J Virol. 2018 Sep 12;92(19). pii: JVI.01057-18. doi: 10.1128/JVI.01057-18. Print 2018 Oct 1. PubMed |
| Downregulation of miR5053p predicts poor bone metastasisfree survival in prostate cancer. Tang Y, Wu B, Huang S, Peng X, Li X, Huang X, Zhou W, Xie P, He P. Oncol Rep. 2019 Jan;41(1):57-66. doi: 10.3892/or.2018.6826. Epub 2018 Oct 25. PubMed |
| Structural Basis for Target-Directed MicroRNA Degradation. Sheu-Gruttadauria J, Pawlica P, Klum SM, Wang S, Yario TA, Schirle Oakdale NT, Steitz JA, MacRae IJ. Mol Cell. 2019 Sep 19;75(6):1243-1255.e7. doi: 10.1016/j.molcel.2019.06.019. Epub 2019 Jul 25. PubMed |
| A Requirement for Argonaute 4 in Mammalian Antiviral Defense. Adiliaghdam F, Basavappa M, Saunders TL, Harjanto D, Prior JT, Cronkite DA, Papavasiliou N, Jeffrey KL. Cell Rep. 2020 Feb 11;30(6):1690-1701.e4. doi: 10.1016/j.celrep.2020.01.021. PubMed |
| AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2. Yang A, Shao TJ, Bofill-De Ros X, Lian C, Villanueva P, Dai L, Gu S. Nat Commun. 2020 Jun 2;11(1):2765. doi: 10.1038/s41467-020-16533-w. PubMed |
| Nuclear role for human Argonaute-1 as an estrogen-dependent transcription coactivator. Gomez Acuna LI, Nazer E, Rodriguez-Segui SA, Pozzi B, Buggiano V, Marasco LE, Agirre E, He C, Allo M, Kornblihtt AR. J Cell Biol. 2020 Sep 7;219(9). pii: 151953. doi: 10.1083/jcb.201908097. PubMed |
| Artificial miRNAs targeting CAG repeat expansion in ORFs cause rapid deadenylation and translation inhibition of mutant transcripts. Ciesiolka A, Stroynowska-Czerwinska A, Joachimiak P, Ciolak A, Kozlowska E, Michalak M, Dabrowska M, Olejniczak M, Raczynska KD, Zielinska D, Wozna-Wysocka M, Krzyzosiak WJ, Fiszer A. Cell Mol Life Sci. 2020 Jul 21. pii: 10.1007/s00018-020-03596-7. doi: 10.1007/s00018-020-03596-7. PubMed |
| An alternative miRISC targets a cancer-associated coding sequence mutation in FOXL2. Shin E, Jin H, Suh DS, Luo Y, Ha HJ, Kim TH, Hahn Y, Hyun S, Lee K, Bae J. EMBO J. 2020 Dec 15;39(24):e104719. doi: 10.15252/embj.2020104719. Epub 2020 Nov 20. PubMed |
| Altering Intracellular Localization of the RNA Interference Factors by Influenza A Virus Non-structural Protein 1. Wang H, Tian Z, Xu Y, Wang Q, Ding SW, Li Y. Front Microbiol. 2020 Nov 12;11:590904. doi: 10.3389/fmicb.2020.590904. eCollection 2020. PubMed |
| Argonaute 2 modulates EGFR-RAS signaling to promote mutant HRAS and NRAS-driven malignancies. Siebenaler RF, Chugh S, Waninger JJ, Dommeti VL, Kenum C, Mody M, Gautam A, Patel N, Chu A, Bawa P, Hon J, Smith RD, Carlson H, Cao X, Tesmer JJG, Shankar S, Chinnaiyan AM. PNAS Nexus. 2022 Jul 28;1(3):pgac084. doi: 10.1093/pnasnexus/pgac084. eCollection 2022 Jul. PubMed |
| TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance. Yang A, Bofill-De Ros X, Stanton R, Shao TJ, Villanueva P, Gu S. Nat Commun. 2022 Sep 7;13(1):5260. doi: 10.1038/s41467-022-32969-8. PubMed |
| Influence of RNA circularity on Target RNA-Directed MicroRNA Degradation. Fuchs Wightman F, Lukin J, Giusti SA, Soutschek M, Bragado L, Pozzi B, Pierelli ML, Gonzalez P, Fededa JP, Schratt G, Fujiwara R, Wilusz JE, Refojo D, de la Mata M. Nucleic Acids Res. 2024 Apr 12;52(6):3358-3374. doi: 10.1093/nar/gkae094. PubMed |
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