LRG2.1 Citations (34)
Originally described in: LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia.Tarumoto Y, Lu B, Somerville TDD, Huang YH, Milazzo JP, Wu XS, Klingbeil O, El Demerdash O, Shi J, Vakoc CR Mol Cell. 2018 Feb 28. pii: S1097-2765(18)30109-6. doi: 10.1016/j.molcel.2018.02.011. PubMed Journal
Articles Citing LRG2.1
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| TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Somerville TDD, Xu Y, Miyabayashi K, Tiriac H, Cleary CR, Maia-Silva D, Milazzo JP, Tuveson DA, Vakoc CR. Cell Rep. 2018 Nov 13;25(7):1741-1755.e7. doi: 10.1016/j.celrep.2018.10.051. PubMed |
| RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening. Verma P, Dilley RL, Zhang T, Gyparaki MT, Li Y, Greenberg RA. Genes Dev. 2019 Feb 1;33(3-4):221-235. doi: 10.1101/gad.319723.118. Epub 2019 Jan 28. PubMed |
Generating Single Cell-Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9.
Giuliano CJ, Lin A, Girish V, Sheltzer JM.
Curr Protoc Mol Biol. 2019 Sep;128(1):e100. doi: 10.1002/cpmb.100.
PubMed
Associated Plasmids |
| Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression. Yuan S, Natesan R, Sanchez-Rivera FJ, Li J, Bhanu NV, Yamazoe T, Lin JH, Merrell AJ, Sela Y, Thomas SK, Jiang Y, Plesset JB, Miller EM, Shi J, Garcia BA, Lowe SW, Asangani IA, Stanger BZ. Cancer Discov. 2020 Jun;10(6):854-871. doi: 10.1158/2159-8290.CD-19-1299. Epub 2020 Mar 18. PubMed |
| Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models. Kim H, Xu H, George E, Hallberg D, Kumar S, Jagannathan V, Medvedev S, Kinose Y, Devins K, Verma P, Ly K, Wang Y, Greenberg RA, Schwartz L, Johnson N, Scharpf RB, Mills GB, Zhang R, Velculescu VE, Brown EJ, Simpkins F. Nat Commun. 2020 Jul 24;11(1):3726. doi: 10.1038/s41467-020-17127-2. PubMed |
| RNA N(6)-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m(6)A-GLUT1-mTORC1 Axis and Is a Therapeutic Target. Chen H, Gao S, Liu W, Wong CC, Wu J, Wu J, Liu D, Gou H, Kang W, Zhai J, Li C, Su H, Wang S, Soares F, Han J, He HH, Yu J. Gastroenterology. 2021 Mar;160(4):1284-1300.e16. doi: 10.1053/j.gastro.2020.11.013. Epub 2020 Nov 18. PubMed |
| Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis. Karayel O, Xu P, Bludau I, Velan Bhoopalan S, Yao Y, Ana Rita FC, Santos A, Schulman BA, Alpi AF, Weiss MJ, Mann M. Mol Syst Biol. 2020 Dec;16(12):e9813. doi: 10.15252/msb.20209813. PubMed |
| ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression. Lan X, Ren R, Feng R, Ly LC, Lan Y, Zhang Z, Aboreden N, Qin K, Horton JR, Grevet JD, Mayuranathan T, Abdulmalik O, Keller CA, Giardine B, Hardison RC, Crossley M, Weiss MJ, Cheng X, Shi J, Blobel GA. Mol Cell. 2021 Jan 21;81(2):239-254.e8. doi: 10.1016/j.molcel.2020.11.006. Epub 2020 Dec 9. PubMed |
| Genetic screening for single-cell variability modulators driving therapy resistance. Torre EA, Arai E, Bayatpour S, Jiang CL, Beck LE, Emert BL, Shaffer SM, Mellis IA, Fane ME, Alicea GM, Budinich KA, Weeraratna AT, Shi J, Raj A. Nat Genet. 2021 Jan;53(1):76-85. doi: 10.1038/s41588-020-00749-z. Epub 2021 Jan 4. PubMed |
| The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure. Chou HC, Bhalla K, Demerdesh OE, Klingbeil O, Hanington K, Aganezov S, Andrews P, Alsudani H, Chang K, Vakoc CR, Schatz MC, McCombie WR, Stillman B. Elife. 2021 Feb 1;10. pii: 61797. doi: 10.7554/eLife.61797. PubMed |
| Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia. Takao S, Forbes L, Uni M, Cheng S, Pineda JMB, Tarumoto Y, Cifani P, Minuesa G, Chen C, Kharas MG, Bradley RK, Vakoc CR, Koche RP, Kentsis A. Elife. 2021 Feb 2;10. pii: 65905. doi: 10.7554/eLife.65905. PubMed |
| Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers. Barua R, Mizuno K, Tashima Y, Ogawa M, Takeuchi H, Taguchi A, Okajima T. Molecules. 2021 Feb 7;26(4). pii: molecules26040882. doi: 10.3390/molecules26040882. PubMed |
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.
Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J.
Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5.
PubMed
Associated Plasmids |
| SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia. Wei Y, Huang YH, Skopelitis DS, Iyer SV, Costa ASH, Yang Z, Kramer M, Adelman ER, Klingbeil O, Demerdash OE, Polyanskaya SA, Chang K, Goodwin S, Hodges E, McCombie WR, Figueroa ME, Vakoc CR. Cancer Discov. 2022 Feb;12(2):450-467. doi: 10.1158/2159-8290.CD-20-1849. Epub 2021 Sep 16. PubMed |
| SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia. Polyanskaya SA, Moreno RY, Lu B, Feng R, Yao Y, Irani S, Klingbeil O, Yang Z, Wei Y, Demerdash OE, Benjamin LA, Weiss MJ, Zhang YJ, Vakoc CR. Cell Rep. 2022 Jan 11;38(2):110233. doi: 10.1016/j.celrep.2021.110233. PubMed |
| DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding. Spangler CJ, Yadav SP, Li D, Geil CN, Smith CB, Wang GG, Lee TH, McGinty RK. Cell Rep. 2022 Feb 15;38(7):110369. doi: 10.1016/j.celrep.2022.110369. PubMed |
| EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells. Zhou Y, Petrovic J, Zhao J, Zhang W, Bigdeli A, Zhang Z, Berger SL, Pear WS, Faryabi RB. Mol Cell. 2022 Mar 3;82(5):1003-1020.e15. doi: 10.1016/j.molcel.2022.01.015. Epub 2022 Feb 18. PubMed |
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers.
Giles JR, Manne S, Freilich E, Oldridge DA, Baxter AE, George S, Chen Z, Huang H, Chilukuri L, Carberry M, Giles L, Weng NP, Young RM, June CH, Schuchter LM, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Huang AC, Shi J, Wherry EJ.
Immunity. 2022 Mar 8;55(3):557-574.e7. doi: 10.1016/j.immuni.2022.02.004.
PubMed
Associated Plasmids |
| OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Wu XS, He XY, Ipsaro JJ, Huang YH, Preall JB, Ng D, Shue YT, Sage J, Egeblad M, Joshua-Tor L, Vakoc CR. Nature. 2022 Jul;607(7917):169-175. doi: 10.1038/s41586-022-04842-7. Epub 2022 May 16. PubMed |
| Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA. Nat Genet. 2022 Jun;54(6):874-884. doi: 10.1038/s41588-022-01076-1. Epub 2022 May 26. PubMed |
| Exposure to escalating olaparib does not induce acquired resistance to PARPi and to other chemotherapeutic compounds in ovarian cancer cell lines. Fedier A, Maggi N, Tozzi A, Disler M, Coelho R, Jacob F, Heinzelmann-Schwarz V. Int J Oncol. 2022 Jul;61(1). pii: 89. doi: 10.3892/ijo.2022.5379. Epub 2022 Jun 1. PubMed |
Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia.
Pingul BY, Huang H, Chen Q, Alikarami F, Zhang Z, Qi J, Bernt KM, Berger SL, Cao Z, Shi J.
iScience. 2022 Sep 15;25(10):105139. doi: 10.1016/j.isci.2022.105139. eCollection 2022 Oct 21.
PubMed
Associated Plasmids |
| Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis. Brooks R, Monzy J, Aaron B, Zhang X, Kossenkov A, Hayden J, Keeney F, Speicher DW, Zhang L, Dang CV. Cell Rep. 2022 Oct 18;41(3):111514. doi: 10.1016/j.celrep.2022.111514. PubMed |
| Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer. Coelho R, Tozzi A, Disler M, Lombardo F, Fedier A, Lopez MN, Freuler F, Jacob F, Heinzelmann-Schwarz V. Cell Death Dis. 2022 Oct 28;13(10):909. doi: 10.1038/s41419-022-05347-x. PubMed |
| BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network. Sun X, Klingbeil O, Lu B, Wu C, Ballon C, Ouyang M, Wu XS, Jin Y, Hwangbo Y, Huang YH, Somerville TDD, Chang K, Park J, Chung T, Lyons SK, Shi J, Vogel H, Schulder M, Vakoc CR, Mills AA. Nature. 2023 Jan;613(7942):195-202. doi: 10.1038/s41586-022-05551-x. Epub 2022 Dec 21. PubMed |
| PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies. Chen S, Paul MR, Sterner CJ, Belka GK, Wang D, Xu P, Sreekumar A, Pan TC, Pant DK, Makhlin I, DeMichele A, Mesaros C, Chodosh LA. Breast Cancer Res. 2023 Jan 3;25(1):1. doi: 10.1186/s13058-022-01559-3. PubMed |
| ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation. Gao Y, He XY, Wu XS, Huang YH, Toneyan S, Ha T, Ipsaro JJ, Koo PK, Joshua-Tor L, Bailey KM, Egeblad M, Vakoc CR. Nat Cell Biol. 2023 Feb;25(2):298-308. doi: 10.1038/s41556-022-01060-1. Epub 2023 Jan 19. PubMed |
| Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance. Li F, Wang Y, Hwang I, Jang JY, Xu L, Deng Z, Yu EY, Cai Y, Wu C, Han Z, Huang YH, Huang X, Zhang L, Yao J, Lue NF, Lieberman PM, Ying H, Paik J, Zheng H. bioRxiv. 2023 Feb 11:2023.02.10.528023. doi: 10.1101/2023.02.10.528023. Preprint. PubMed |
| A bioengineered immunocompetent human leukemia chip for preclinical screening of CAR T cell immunotherapy. Chen W, Ma C, Wang H, Liu L, Tong J, Witkowski M, Aifantis I, Ghassemi S. Res Sq. 2023 Apr 21:rs.3.rs-2762929. doi: 10.21203/rs.3.rs-2762929/v1. Preprint. PubMed |
| Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy. Kim IK, Diamond M, Yuan S, Kemp S, Li Q, Lin J, Li J, Norgard R, Thomas S, Merolle M, Katsuda T, Tobias J, Politi K, Vonderheide R, Stanger B. Res Sq. 2023 Jun 1:rs.3.rs-2960521. doi: 10.21203/rs.3.rs-2960521/v1. Preprint. PubMed |
| Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR. Zong D, Koussa NC, Cornwell JA, Pankajam AV, Kruhlak MJ, Wong N, Chari R, Cappell SD, Nussenzweig A. Genes Dev. 2023 Oct 1;37(19-20):913-928. doi: 10.1101/gad.351085.123. Epub 2023 Nov 6. PubMed |
| IkappaBzeta is a dual-use coactivator of NF-kappaB and POU transcription factors. Alpsoy A, Wu XS, Pal S, Klingbeil O, Kumar P, El Demerdash O, Nalbant B, Vakoc CR. Mol Cell. 2024 Mar 21;84(6):1149-1157.e7. doi: 10.1016/j.molcel.2024.01.007. Epub 2024 Feb 2. PubMed |
| Genetic dependencies associated with transcription factor activities in human cancer cell lines. Thatikonda V, Supper V, Wachter J, Kaya O, Kombara A, Bilgilier C, Ravichandran MC, Lipp JJ, Sharma R, Badertscher L, Boghossian AS, Rees MG, Ronan MM, Roth JA, Grosche S, Neumuller RA, Mair B, Mauri F, Popa A. Cell Rep. 2024 May 28;43(5):114175. doi: 10.1016/j.celrep.2024.114175. Epub 2024 Apr 30. PubMed |
| CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy. Qin M, Deng C, Wen L, Luo G, Meng Y. J Transl Med. 2024 May 30;22(1):516. doi: 10.1186/s12967-024-05235-2. PubMed |
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