pJ4M/TDP-43 Citations (16)
Originally described in: A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL EMBO J. 2018 Mar 1;37(5). pii: embj.201797452. doi: 10.15252/embj.201797452. Epub 2018 Feb 9. PubMed Journal
Articles Citing pJ4M/TDP-43
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| Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization. McGurk L, Gomes E, Guo L, Mojsilovic-Petrovic J, Tran V, Kalb RG, Shorter J, Bonini NM. Mol Cell. 2018 Sep 6;71(5):703-717.e9. doi: 10.1016/j.molcel.2018.07.002. Epub 2018 Aug 9. PubMed |
| RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, Brodsky JL, Thathiah A, Shorter J, Donnelly CJ. Neuron. 2019 Feb 27. pii: S0896-6273(19)30075-3. doi: 10.1016/j.neuron.2019.01.048. PubMed |
| SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins. Perdikari TM, Murthy AC, Ryan VH, Watters S, Naik MT, Fawzi NL. bioRxiv. 2020 Jun 10. doi: 10.1101/2020.06.09.141101. PubMed |
| Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Babinchak WM, Dumm BK, Venus S, Boyko S, Putnam AA, Jankowsky E, Surewicz WK. Nat Commun. 2020 Nov 4;11(1):5574. doi: 10.1038/s41467-020-19211-z. PubMed |
SARS-CoV-2 nucleocapsid protein phase-separates with RNA and with human hnRNPs.
Perdikari TM, Murthy AC, Ryan VH, Watters S, Naik MT, Fawzi NL.
EMBO J. 2020 Nov 17:e106478. doi: 10.15252/embj.2020106478.
PubMed
Associated Plasmids |
| Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions. Hutten S, Usluer S, Bourgeois B, Simonetti F, Odeh HM, Fare CM, Czuppa M, Hruska-Plochan M, Hofweber M, Polymenidou M, Shorter J, Edbauer D, Madl T, Dormann D. Cell Rep. 2020 Dec 22;33(12):108538. doi: 10.1016/j.celrep.2020.108538. PubMed |
| TDP-43 condensation properties specify its RNA-binding and regulatory repertoire. Hallegger M, Chakrabarti AM, Lee FCY, Lee BL, Amalietti AG, Odeh HM, Copley KE, Rubien JD, Portz B, Kuret K, Huppertz I, Rau F, Patani R, Fawzi NL, Shorter J, Luscombe NM, Ule J. Cell. 2021 Sep 2;184(18):4680-4696.e22. doi: 10.1016/j.cell.2021.07.018. Epub 2021 Aug 10. PubMed |
| TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A. Ma XR, Prudencio M, Koike Y, Vatsavayai SC, Kim G, Harbinski F, Briner A, Rodriguez CM, Guo C, Akiyama T, Schmidt HB, Cummings BB, Wyatt DW, Kurylo K, Miller G, Mekhoubad S, Sallee N, Mekonnen G, Ganser L, Rubien JD, Jansen-West K, Cook CN, Pickles S, Oskarsson B, Graff-Radford NR, Boeve BF, Knopman DS, Petersen RC, Dickson DW, Shorter J, Myong S, Green EM, Seeley WW, Petrucelli L, Gitler AD. Nature. 2022 Mar;603(7899):124-130. doi: 10.1038/s41586-022-04424-7. Epub 2022 Feb 23. PubMed |
| Sequestration of TDP-43(216-414) Aggregates by Cytoplasmic Expression of the proSAAS Chaperone. Peinado JR, Chaplot K, Jarvela TS, Barbieri EM, Shorter J, Lindberg I. ACS Chem Neurosci. 2022 Jun 1;13(11):1651-1665. doi: 10.1021/acschemneuro.2c00156. Epub 2022 May 12. PubMed |
| Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation. Shen H, Yanas A, Owens MC, Zhang C, Fritsch C, Fare CM, Copley KE, Shorter J, Goldman YE, Liu KF. Mol Cell. 2022 Jul 21;82(14):2588-2603.e9. doi: 10.1016/j.molcel.2022.04.022. Epub 2022 May 18. PubMed |
| C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD. Ervilha Pereira P, Schuermans N, Meylemans A, LeBlanc P, Versluys L, Copley KE, Rubien JD, Altheimer C, Peetermans M, Debackere E, Vanakker O, Janssens S, Baets J, Verhoeven K, Lammens M, Symoens S, De Paepe B, Barmada SJ, Shorter J, De Bleecker JL, Bogaert E, Dermaut B. Acta Neuropathol. 2023 Jun;145(6):793-814. doi: 10.1007/s00401-023-02565-1. Epub 2023 Mar 31. PubMed |
| Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns. Perez-Berlanga M, Wiersma VI, Zbinden A, De Vos L, Wagner U, Foglieni C, Mallona I, Betz KM, Clery A, Weber J, Guo Z, Rigort R, de Rossi P, Manglunia R, Tantardini E, Sahadevan S, Stach O, Hruska-Plochan M, Allain FH, Paganetti P, Polymenidou M. EMBO J. 2023 Jul 11:e111719. doi: 10.15252/embj.2022111719. PubMed |
| Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo. Riemenschneider H, Simonetti F, Sheth U, Katona E, Roth S, Hutten S, Farny D, Michaelsen M, Nuscher B, Schmidt MK, Flatley A, Schepers A, Gruijs da Silva LA, Zhou Q, Klopstock T, Liesz A, Arzberger T, Herms J, Feederle R, Gendron TF, Dormann D, Edbauer D. Acta Neuropathol Commun. 2023 Jul 11;11(1):112. doi: 10.1186/s40478-023-01592-z. PubMed |
| DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones. Abayev-Avraham M, Salzberg Y, Gliksberg D, Oren-Suissa M, Rosenzweig R. Nat Commun. 2023 Nov 3;14(1):7066. doi: 10.1038/s41467-023-42735-z. PubMed |
| The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis. Zibold J, Lessard LER, Picard F, da Silva LG, Zadorozhna Y, Streichenberger N, Belotti E, Osseni A, Emerit A, Errazuriz-Cerda E, Michel-Calemard L, Menassa R, Coudert L, Wiessner M, Stucka R, Klopstock T, Simonetti F, Hutten S, Nonaka T, Hasegawa M, Strom TM, Bernard E, Ollagnon E, Urtizberea A, Dormann D, Petiot P, Schaeffer L, Senderek J, Leblanc P. Brain. 2023 Dec 11:awad410. doi: 10.1093/brain/awad410. PubMed |
| Seeding competent TDP-43 persists in human patient and mouse muscle. Lynch EM, Pittman S, Daw J, Ikenaga C, Chen S, Dhavale DD, Jackrel ME, Ayala YM, Kotzbauer P, Ly CV, Pestronk A, Lloyd TE, Weihl CC. bioRxiv [Preprint]. 2024 Apr 4:2024.04.03.587918. doi: 10.1101/2024.04.03.587918. PubMed |
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