pLJC5-Tmem192-3xHA Citations (28)
Originally described in: Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes.Abu-Remaileh M, Wyant GA, Kim C, Laqtom NN, Abbasi M, Chan SH, Freinkman E, Sabatini DM Science. 2017 Nov 10;358(6364):807-813. doi: 10.1126/science.aan6298. Epub 2017 Oct 26. PubMed Journal
Articles Citing pLJC5-Tmem192-3xHA
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| Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72. Laflamme C, McKeever PM, Kumar R, Schwartz J, Kolahdouzan M, Chen CX, You Z, Benaliouad F, Gileadi O, McBride HM, Durcan TM, Edwards AM, Healy LM, Robertson J, McPherson PS. Elife. 2019 Oct 15;8. pii: 48363. doi: 10.7554/eLife.48363. PubMed |
| Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo. Yambire KF, Rostosky C, Watanabe T, Pacheu-Grau D, Torres-Odio S, Sanchez-Guerrero A, Senderovich O, Meyron-Holtz EG, Milosevic I, Frahm J, West AP, Raimundo N. Elife. 2019 Dec 3;8. pii: 51031. doi: 10.7554/eLife.51031. PubMed |
| Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal. Jia J, Claude-Taupin A, Gu Y, Choi SW, Peters R, Bissa B, Mudd MH, Allers L, Pallikkuth S, Lidke KA, Salemi M, Phinney B, Mari M, Reggiori F, Deretic V. Dev Cell. 2020 Jan 6;52(1):69-87.e8. doi: 10.1016/j.devcel.2019.10.025. Epub 2019 Dec 5. PubMed |
| Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis. Cui W, Sathyanarayan A, Lopresti M, Aghajan M, Chen C, Mashek DG. Autophagy. 2020 Feb 19:1-16. doi: 10.1080/15548627.2020.1728097. PubMed |
MFSD12 mediates the import of cysteine into melanosomes and lysosomes.
Adelmann CH, Traunbauer AK, Chen B, Condon KJ, Chan SH, Kunchok T, Lewis CA, Sabatini DM.
Nature. 2020 Nov 18. pii: 10.1038/s41586-020-2937-x. doi: 10.1038/s41586-020-2937-x.
PubMed
Associated Plasmids |
| Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11. Mukhopadhyay S, Biancur DE, Parker SJ, Yamamoto K, Banh RS, Paulo JA, Mancias JD, Kimmelman AC. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6). pii: 2021475118. doi: 10.1073/pnas.2021475118. PubMed |
| Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress. Devenport SN, Singhal R, Radyk MD, Taranto JG, Kerk SA, Chen B, Goyert JW, Jain C, Das NK, Oravecz-Wilson K, Zhang L, Greenson JK, Chen YE, Soleimanpour SA, Reddy P, Lyssiotis CA, Shah YM. JCI Insight. 2021 Jun 17;6(14). pii: e138835. doi: 10.1172/jci.insight.138835. PubMed |
| Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins. Fote GM, Geller NR, Efstathiou NE, Hendricks N, Vavvas DG, Reidling JC, Thompson LM, Steffan JS. J Cell Sci. 2022 Jan 15;135(2). pii: 274103. doi: 10.1242/jcs.258687. Epub 2022 Jan 25. PubMed |
| Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency. Wang F, Yang Y, Boudagh G, Eskelinen EL, Klionsky DJ, Malek SN. Autophagy. 2022 Aug;18(8):1982-2000. doi: 10.1080/15548627.2022.2050663. Epub 2022 Mar 24. PubMed |
| An infection-induced oxidation site regulates legumain processing and tumor growth. Kovalyova Y, Bak DW, Gordon EM, Fung C, Shuman JHB, Cover TL, Amieva MR, Weerapana E, Hatzios SK. Nat Chem Biol. 2022 Jul;18(7):698-705. doi: 10.1038/s41589-022-00992-x. Epub 2022 Mar 24. PubMed |
| Current methods to analyze lysosome morphology, positioning, motility and function. Barral DC, Staiano L, Guimas Almeida C, Cutler DF, Eden ER, Futter CE, Galione A, Marques ARA, Medina DL, Napolitano G, Settembre C, Vieira OV, Aerts JMFG, Atakpa-Adaji P, Bruno G, Capuozzo A, De Leonibus E, Di Malta C, Escrevente C, Esposito A, Grumati P, Hall MJ, Teodoro RO, Lopes SS, Luzio JP, Monfregola J, Montefusco S, Platt FM, Polishchuck R, De Risi M, Sambri I, Soldati C, Seabra MC. Traffic. 2022 May;23(5):238-269. doi: 10.1111/tra.12839. Epub 2022 Apr 24. PubMed |
| Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity. Saffi GT, Wang CA, Mangialardi EM, Vacher J, Botelho RJ, Salmena L. J Biol Chem. 2022 Aug;298(8):102187. doi: 10.1016/j.jbc.2022.102187. Epub 2022 Jun 26. PubMed |
| The endoplasmic reticulum contributes to lysosomal tubulation/sorting driven by LRRK2. Bonet-Ponce L, Cookson MR. Mol Biol Cell. 2022 Nov 1;33(13):ar124. doi: 10.1091/mbc.E22-04-0139. Epub 2022 Aug 31. PubMed |
| Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition. Figlia G, Muller S, Hagenston AM, Kleber S, Roiuk M, Quast JP, Ten Bosch N, Carvajal Ibanez D, Mauceri D, Martin-Villalba A, Teleman AA. Nat Cell Biol. 2022 Sep;24(9):1407-1421. doi: 10.1038/s41556-022-00977-x. Epub 2022 Sep 12. PubMed |
| Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism. Cavounidis A, Pandey S, Capitani M, Friedrich M, Cross A, Gartner L, Aschenbrenner D, Kim-Schulze S, Lam YK, Berridge G, McGovern DPB, Kessler B, Fischer R, Klenerman P, Hester J, Issa F, Torres EA, Powrie F, Gochuico BR, Gahl WA, Cohen L, Uhlig HH. Mucosal Immunol. 2022 Jun;15(6):1431-1446. doi: 10.1038/s41385-022-00572-1. Epub 2022 Oct 27. PubMed |
| Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis. Zhang S, Lee SH, Nie L, Huang Y, Zou G, Jung YS, Jun S, Zhang J, Lien EM, Chen J, Park JI. Cancer Commun (Lond). 2023 Jan;43(1):159-163. doi: 10.1002/cac2.12382. Epub 2022 Nov 6. PubMed |
| mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species. Hosios AM, Wilkinson ME, McNamara MC, Kalafut KC, Torrence ME, Asara JM, Manning BD. Nat Metab. 2022 Dec;4(12):1792-1811. doi: 10.1038/s42255-022-00706-6. Epub 2022 Dec 19. PubMed |
| The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy. Gallagher ER, Holzbaur ELF. Cell Rep. 2023 Feb 28;42(2):112037. doi: 10.1016/j.celrep.2023.112037. Epub 2023 Jan 25. PubMed |
| An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation. Scharenberg SG, Dong W, Ghoochani A, Nyame K, Levin-Konigsberg R, Krishnan AR, Rawat ES, Spees K, Bassik MC, Abu-Remaileh M. Sci Adv. 2023 Apr 21;9(16):eadf8966. doi: 10.1126/sciadv.adf8966. Epub 2023 Apr 19. PubMed |
| Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1. Malik N, Ferreira BI, Hollstein PE, Curtis SD, Trefts E, Weiser Novak S, Yu J, Gilson R, Hellberg K, Fang L, Sheridan A, Hah N, Shadel GS, Manor U, Shaw RJ. Science. 2023 Apr 21;380(6642):eabj5559. doi: 10.1126/science.abj5559. Epub 2023 Apr 21. PubMed |
| An ATG12-ATG5-TECPR1 E3-like complex regulates unconventional LC3 lipidation at damaged lysosomes. Corkery DP, Castro-Gonzalez S, Knyazeva A, Herzog LK, Wu YW. EMBO Rep. 2023 Sep 6;24(9):e56841. doi: 10.15252/embr.202356841. Epub 2023 Jun 29. PubMed |
| Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion. Gutierrez-Ruiz OL, Johnson KM, Krueger EW, Nooren RE, Cruz-Reyes N, Heppelmann CJ, Hogenson TL, Fernandez-Zapico ME, McNiven MA, Razidlo GL. Cell Rep. 2023 Sep 26;42(9):113042. doi: 10.1016/j.celrep.2023.113042. Epub 2023 Aug 30. PubMed |
The TMEM192-mKeima probe specifically assays lysophagy and reveals its initial steps.
Shima T, Ogura M, Matsuda R, Nakamura S, Jin N, Yoshimori T, Kuma A.
J Cell Biol. 2023 Dec 4;222(12):e202204048. doi: 10.1083/jcb.202204048. Epub 2023 Oct 6.
PubMed
Associated Plasmids |
| Lysosomal proteomics reveals mechanisms of neuronal apoE4associated lysosomal dysfunction. Krogsaeter EK, McKetney J, Marquez A, Cakir Z, Stevenson E, Jang GM, Rao A, Zhou A, Huang Y, Krogan NJ, Swaney DL. bioRxiv [Preprint]. 2023 Oct 2:2023.10.02.560519. doi: 10.1101/2023.10.02.560519. PubMed |
| L-Type Amino Acid Transporter 1 (LAT1) Promotes PMA-Induced Cell Migration through mTORC2 Activation at the Lysosome. Tae K, Kim SJ, Cho SW, Lee H, Cha HS, Choi CY. Cells. 2023 Oct 23;12(20):2504. doi: 10.3390/cells12202504. PubMed |
| DENND6A links Arl8b to a Rab34/RILP/dynein complex, regulating lysosomal positioning and autophagy. Kumar R, Khan M, Francis V, Aguila A, Kulasekaran G, Banks E, McPherson PS. Nat Commun. 2024 Jan 31;15(1):919. doi: 10.1038/s41467-024-44957-1. PubMed |
| PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes. Singh S, Dransfeld U, Ambaw Y, Lopez-Scarim J, Farese RV Jr, Walther TC. bioRxiv [Preprint]. 2024 Mar 21:2024.03.21.586175. doi: 10.1101/2024.03.21.586175. PubMed |
| Lysosomal dysfunction and overload of nucleosides in thymidine phosphorylase deficiency of MNGIE. Du J, Liu F, Liu X, Zhao D, Wang D, Sun H, Yan C, Zhao Y. J Transl Med. 2024 May 13;22(1):449. doi: 10.1186/s12967-024-05275-8. PubMed |
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