BPK4410 - human expression plasmid for SpCas9 Cluster 1 (HypaCas9) Citations (4)
Originally described in: Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.Chen JS, Dagdas YS, Kleinstiver BP, Welch MM, Sousa AA, Harrington LB, Sternberg SH, Joung JK, Yildiz A, Doudna JA Nature. 2017 Sep 20. doi: 10.1038/nature24268. PubMed Journal
Articles Citing BPK4410 - human expression plasmid for SpCas9 Cluster 1 (HypaCas9)
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Directed evolution of CRISPR-Cas9 to increase its specificity.
Lee JK, Jeong E, Lee J, Jung M, Shin E, Kim YH, Lee K, Jung I, Kim D, Kim S, Kim JS.
Nat Commun. 2018 Aug 6;9(1):3048. doi: 10.1038/s41467-018-05477-x.
PubMed
Associated Plasmids |
| MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits. Ma L, Ruan J, Song J, Wen L, Yang D, Zhao J, Xia X, Chen YE, Zhang J, Xu J. Nat Commun. 2020 Nov 27;11(1):6082. doi: 10.1038/s41467-020-19842-2. PubMed |
| Quantitative assessment of engineered Cas9 variants for target specificity enhancement by single-molecule reaction pathway analysis. Bak SY, Jung Y, Park J, Sung K, Jang HK, Bae S, Kim SK. Nucleic Acids Res. 2021 Nov 8;49(19):11312-11322. doi: 10.1093/nar/gkab858. PubMed |
| Deleting specific residues from the HNH linkers creates a CRISPR-SpCas9 variant with high fidelity and efficiency. Wang G, Wang C, Chu T, Wu X, Anderson CM, Huang D, Li J. J Biotechnol. 2023 May 20;368:42-52. doi: 10.1016/j.jbiotec.2023.04.008. Epub 2023 Apr 26. PubMed |
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