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BE4-Gam Citations (17)

Originally described in: Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity.
Komor AC, Zhao KT, Packer MS, Gaudelli NM, Waterbury AL, Koblan LW, Kim YB, Badran AH, Liu DR Sci Adv. 2017 Aug 30;3(8):eaao4774. doi: 10.1126/sciadv.aao4774. eCollection 2017 Aug. PubMed Journal

Articles Citing BE4-Gam

Articles
Highly efficient RNA-guided base editing in rabbit. Liu Z, Chen M, Chen S, Deng J, Song Y, Lai L, Li Z. Nat Commun. 2018 Jul 13;9(1):2717. doi: 10.1038/s41467-018-05232-2. PubMed
Expanded targeting scope and enhanced base editing efficiency in rabbit using optimized xCas9(3.7). Liu Z, Chen M, Shan H, Chen S, Xu Y, Song Y, Zhang Q, Yuan H, Ouyang H, Li Z, Lai L. Cell Mol Life Sci. 2019 Apr 27. pii: 10.1007/s00018-019-03110-8. doi: 10.1007/s00018-019-03110-8. PubMed
Mutations of GADD45G in rabbits cause cleft lip by the disorder of proliferation, apoptosis and epithelial-mesenchymal transition (EMT). Lu Y, Liang M, Zhang Q, Liu Z, Song Y, Lai L, Li Z. Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2356-2367. doi: 10.1016/j.bbadis.2019.05.015. Epub 2019 May 29. PubMed
Efficient base editing by RNA-guided cytidine base editors (CBEs) in pigs. Yuan H, Yu T, Wang L, Yang L, Zhang Y, Liu H, Li M, Tang X, Liu Z, Li Z, Lu C, Chen X, Pang D, Ouyang H. Cell Mol Life Sci. 2019 Jul 13. pii: 10.1007/s00018-019-03205-2. doi: 10.1007/s00018-019-03205-2. PubMed
A transient reporter for editing enrichment (TREE) in human cells. Standage-Beier K, Tekel SJ, Brookhouser N, Schwarz G, Nguyen T, Wang X, Brafman DA. Nucleic Acids Res. 2019 Aug 20. pii: 5552066. doi: 10.1093/nar/gkz713. PubMed

Associated Plasmids
A qPCR method for genome editing efficiency determination and single-cell clone screening in human cells. Li B, Ren N, Yang L, Liu J, Huang Q. Sci Rep. 2019 Dec 11;9(1):18877. doi: 10.1038/s41598-019-55463-6. PubMed
Efficient base editing with high precision in rabbits using YFE-BE4max. Liu Z, Chen S, Shan H, Jia Y, Chen M, Song Y, Lai L, Li Z. Cell Death Dis. 2020 Jan 20;11(1):36. doi: 10.1038/s41419-020-2244-3. PubMed
Enabling large-scale genome editing at repetitive elements by reducing DNA nicking. Smith CJ, Castanon O, Said K, Volf V, Khoshakhlagh P, Hornick A, Ferreira R, Wu CT, Guell M, Garg S, Ng AHM, Myllykallio H, Church GM. Nucleic Acids Res. 2020 May 21;48(9):5183-5195. doi: 10.1093/nar/gkaa239. PubMed

Associated Plasmids
Multiplex precise base editing in cynomolgus monkeys. Zhang W, Aida T, Del Rosario RCH, Wilde JJ, Ding C, Zhang X, Baloch Z, Huang Y, Tang Y, Li D, Lu H, Zhou Y, Jiang M, Xu D, Fang Z, Zheng Z, Huang Q, Feng G, Yang S. Nat Commun. 2020 May 11;11(1):2325. doi: 10.1038/s41467-020-16173-0. PubMed
A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth. Papke CM, Smolen KA, Swingle MR, Cressey L, Heng RA, Toporsian M, Deng L, Hagen J, Shen Y, Chung WK, Kettenbach AN, Honkanen RE. J Biol Chem. 2021 Jan-Jun;296:100313. doi: 10.1016/j.jbc.2021.100313. Epub 2021 Jan 20. PubMed
Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish. Rosello M, Vougny J, Czarny F, Mione MC, Concordet JP, Albadri S, Del Bene F. Elife. 2021 Feb 12;10. pii: 65552. doi: 10.7554/eLife.65552. PubMed
Identification and characterization of a novel mutant isocitrate dehydrogenase 1 inhibitor for glioma treatment. Zhang N, Zheng B, Yao X, Huang X, Du J, Shen Y, Huang Z, Chen J, Lin Q, Lan W, Lin W, Ma W. Biochem Biophys Res Commun. 2021 Apr 30;551:38-45. doi: 10.1016/j.bbrc.2021.02.112. Epub 2021 Mar 11. PubMed
Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro. Guyon A, Rousseau J, Begin FG, Bertin T, Lamothe G, Tremblay JP. Mol Ther Nucleic Acids. 2021 Mar 1;24:253-263. doi: 10.1016/j.omtn.2021.02.032. eCollection 2021 Jun 4. PubMed
Boosting targeted genome editing using the hei-tag. Thumberger T, Tavhelidse-Suck T, Gutierrez-Triana JA, Cornean A, Medert R, Welz B, Freichel M, Wittbrodt J. Elife. 2022 Mar 25;11. pii: 70558. doi: 10.7554/eLife.70558. PubMed

Associated Plasmids
Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites. Tao J, Wang Q, Mendez-Dorantes C, Burns KH, Chiarle R. Nat Commun. 2022 Jun 27;13(1):3685. doi: 10.1038/s41467-022-31322-3. PubMed
PAM-flexible Cas9-mediated base editing of a hemophilia B mutation in induced pluripotent stem cells. Hiramoto T, Kashiwakura Y, Hayakawa M, Baatartsogt N, Kamoshita N, Abe T, Inaba H, Nishimasu H, Uosaki H, Hanazono Y, Nureki O, Ohmori T. Commun Med (Lond). 2023 Apr 19;3(1):56. doi: 10.1038/s43856-023-00286-w. PubMed
Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation. Li Q, Lu J, Yin X, Chang Y, Wang C, Yan M, Feng L, Cheng Y, Gao Y, Xu B, Zhang Y, Wang Y, Cui G, Xu L, Sun Y, Zeng R, Li Y, Jing N, Xu GL, Wu L, Tang F, Li J. Nat Commun. 2023 May 22;14(1):2922. doi: 10.1038/s41467-023-38528-z. PubMed

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