A conserved set of mutations for stabilizing soluble envelope protein dimers from dengue and Zika viruses to advance the development of subunit vaccines.
Phan TTN, Hvasta MG, Kudlacek ST, Thiono DJ, Tripathy A, Nicely NI, de Silva AM, Kuhlman B
J Biol Chem. 2022 Jul;298(7):102079. doi: 10.1016/j.jbc.2022.102079. Epub 2022 May 26. PubMed Article
Phan TTN, Hvasta MG, Kudlacek ST, Thiono DJ, Tripathy A, Nicely NI, de Silva AM, Kuhlman B
J Biol Chem. 2022 Jul;298(7):102079. doi: 10.1016/j.jbc.2022.102079. Epub 2022 May 26. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 219718 | pD1sE_SC12 | DV1 E dimer with fusion loop mutation and increased expression |
| 219719 | pD2sE_SC12 | DV2 stable E dimer with fusion loop mutation and increased expression |
| 219720 | pD3sE_SC12 | DV3 E dimer with fusion loop mutation and increased expression |
| 219721 | pD4sE_SC12 | DV4 stable E dimer with fusion loop mutation and increased expression |
| 219722 | pZVsE_SC12 | Zika virus stable E dimer with fusion loop mutation and increased expression |