Circuit-specific gene therapy reverses core symptoms in a primate Parkinson's disease model.
Chen Y, Hong Z, Wang J, Liu K, Liu J, Lin J, Feng S, Zhang T, Shan L, Liu T, Guo P, Lin Y, Li T, Chen Q, Jiang X, Li A, Li X, Li Y, Wilde JJ, Bao J, Dai J, Lu Z
Cell. 2023 Nov 22;186(24):5394-5410.e18. doi: 10.1016/j.cell.2023.10.004. Epub 2023 Nov 2. PubMed Article
Chen Y, Hong Z, Wang J, Liu K, Liu J, Lin J, Feng S, Zhang T, Shan L, Liu T, Guo P, Lin Y, Li T, Chen Q, Jiang X, Li A, Li X, Li Y, Wilde JJ, Bao J, Dai J, Lu Z
Cell. 2023 Nov 22;186(24):5394-5410.e18. doi: 10.1016/j.cell.2023.10.004. Epub 2023 Nov 2. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 213968 | AAV8R-12 Capsid | AAV packaging vector carrying AAV2 rep gene and Cap8R modified AAV8 capsid coding sequence |
| 213969 | pAAV-pCALM1-sFLEx-HA-SpCas9-miniU6-sgRNAShank3 | AAV vector for encoding SpCas9 driven by pCALM1 promoter targeting Shank3 locus in the presence of Cre recombinase |
| 213970 | pAAV-G88P7-rM3Ds-2A-EYFP | AAV vector with G88P7 promoter in order to induce robust gene expression in MSNs |