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Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution.

Starr TN, Greaney AJ, Hannon WW, Loes AN, Hauser K, Dillen JR, Ferri E, Farrell AG, Dadonaite B, McCallum M, Matreyek KA, Corti D, Veesler D, Snell G, Bloom JD
Science. 2022 Jun 28:eabo7896. doi: 10.1126/science.abo7896. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
1844043019_pETcon-SARS-CoV-2-RBD_E484Kyeast surface display of the SARS-CoV-2 Eta variant RBD
1844053020_pETcon-SARS-CoV-2-RBD_N501Yyeast surface display of the SARS-CoV-2 Alpha variant RBD
1844063021_pETcon-SARS-CoV-2-RBD_K417N_E484K_N501Yyeast surface display of the SARS-CoV-2 Beta variant RBD
1844073159_pETcon-SARS-CoV-2-RBD-L452R-T478Kyeast surface display of the SARS-CoV-2 Delta variant RBD
1844083294_pETcon-SARS2-RBD_Omicron-BA1yeast surface display of the SARS-CoV-2 Omicron BA.1 variant RBD
1844093322_pETcon_SARS2_Omicron-BA2yeast surface display of the SARS-CoV-2 Omicron BA.2 variant RBD

Antibodies from Article