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pInducer20 Citations (154)

Originally described in: The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo.
Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3665-70. doi: 10.1073/pnas.1019736108. Epub 2011 Feb 9.
PubMed Journal

Articles Citing pInducer20

Articles
Coordinated regulation of autophagy and apoptosis determines endothelial cell fate during Dengue virus type 2 infection. Huang J, Li Y, Qi Y, Zhang Y, Zhang L, Wang Z, Zhang X, Gui L. Mol Cell Biochem. 2014 Dec;397(1-2):157-65. doi: 10.1007/s11010-014-2183-3. Epub 2014 Aug 20. PubMed
FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1). Kloet DE, Polderman PE, Eijkelenboom A, Smits LM, van Triest MH, van den Berg MC, Groot Koerkamp MJ, van Leenen D, Lijnzaad P, Holstege FC, Burgering BM. Biochem J. 2015 Jul 15;469(2):289-98. doi: 10.1042/BJ20140831. Epub 2015 May 20. PubMed
Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells. Kawprasertsri S, Pietras RJ, Marquez-Garban DC, Boonyaratanakornkit V. Cancer Lett. 2016 May 1;374(2):279-91. doi: 10.1016/j.canlet.2016.02.014. Epub 2016 Feb 15. PubMed
At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells. Rozovski U, Harris DM, Li P, Liu Z, Wu JY, Grgurevic S, Faderl S, Ferrajoli A, Wierda WG, Martinez M, Verstovsek S, Keating MJ, Estrov Z. J Immunol. 2016 May 15;196(10):4400-9. doi: 10.4049/jimmunol.1402108. Epub 2016 Apr 13. PubMed
Transformation by Polyomavirus Middle T Antigen Involves A Unique Bimodal Interaction with the Hippo Effector YAP. Rouleau C, Pores Fernando AT, Hwang JH, Faure N, Jiang T, White EA, Roberts TM, Schaffhausen BS. J Virol. 2016 May 18. pii: JVI.00417-16. PubMed
A PPARgamma-Bnip3 axis couples adipose mitochondrial fusion-fission balance to systemic insulin sensitivity. Tol MJ, Ottenhoff R, van Eijk M, Zelcer N, Aten J, Houten SM, Geerts D, van Roomen C, Bierlaagh MC, Scheij S, Hoeksema MA, Aerts JM, Bogan JS, Dorn GW 2nd, Argmann CA, Verhoeven AJ. Diabetes. 2016 Jun 20. pii: db160243. PubMed
Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures. Kesarwani AK, Ramirez O, Gupta AK, Yang X, Murthy T, Minella AC, Pillai MM. Oncogene. 2016 Aug 15. doi: 10.1038/onc.2016.279. PubMed

Associated Plasmids

hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Eshtad S, Mavajian Z, Rudd SG, Visnes T, Bostrom J, Altun M, Helleday T. Oncogenesis. 2016 Dec 5;5(12):e275. doi: 10.1038/oncsis.2016.72. PubMed
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Adamson B, Norman TM, Jost M, Cho MY, Nunez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS. Cell. 2016 Dec 15;167(7):1867-1882.e21. doi: 10.1016/j.cell.2016.11.048. PubMed

Associated Plasmids

Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. Liau BB, Sievers C, Donohue LK, Gillespie SM, Flavahan WA, Miller TE, Venteicher AS, Hebert CH, Carey CD, Rodig SJ, Shareef SJ, Najm FJ, van Galen P, Wakimoto H, Cahill DP, Rich JN, Aster JC, Suva ML, Patel AP, Bernstein BE. Cell Stem Cell. 2016 Dec 2. pii: S1934-5909(16)30399-X. doi: 10.1016/j.stem.2016.11.003. PubMed
Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas. Piunti A, Hashizume R, Morgan MA, Bartom ET, Horbinski CM, Marshall SA, Rendleman EJ, Ma Q, Takahashi YH, Woodfin AR, Misharin AV, Abshiru NA, Lulla RR, Saratsis AM, Kelleher NL, James CD, Shilatifard A. Nat Med. 2017 Apr;23(4):493-500. doi: 10.1038/nm.4296. Epub 2017 Feb 27. PubMed
Prmt1-mediated translation regulation is a crucial vulnerability of cancer. Hsu JH, Hubbell-Engler B, Adelmant G, Huang J, Joyce CE, Vazquez F, Weir BA, Montgomery P, Tsherniak A, Giacomelli AO, Perry JA, Trowbridge J, Fujiwara Y, Cowley GS, Xie H, Kim W, Novina CD, Hahn WC, Marto JA, Orkin SH. Cancer Res. 2017 Jun 27. pii: canres.0216.2017. doi: 10.1158/0008-5472.CAN-17-0216. PubMed
Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma. Britton E, Rogerson C, Mehta S, Li Y, Li X, Fitzgerald RC, Ang YS, Sharrocks AD. PLoS Genet. 2017 Aug 31;13(8):e1006879. doi: 10.1371/journal.pgen.1006879. eCollection 2017 Aug. PubMed
A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. Slemmons KK, Crose LES, Riedel S, Sushnitha M, Belyea B, Linardic CM. Mol Cancer Res. 2017 Dec;15(12):1777-1791. doi: 10.1158/1541-7786.MCR-17-0004. Epub 2017 Sep 18. PubMed
Rapid DNA replication origin licensing protects stem cell pluripotency. Matson JP, Dumitru R, Coryell P, Baxley RM, Chen W, Twaroski K, Webber BR, Tolar J, Bielinsky AK, Purvis JE, Cook JG. Elife. 2017 Nov 17;6. doi: 10.7554/eLife.30473. PubMed

Associated Plasmids

FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression. Hornsveld M, Smits LMM, Meerlo M, van Amersfoort M, Groot Koerkamp MJA, van Leenen D, Kloet DEA, Holstege FCP, Derksen PWB, Burgering BMT, Dansen TB. Cancer Res. 2018 May 1;78(9):2356-2369. doi: 10.1158/0008-5472.CAN-17-2511. Epub 2018 Feb 12. PubMed
Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors. Hwang I, Cao D, Na Y, Kim DY, Zhang T, Yao J, Oh H, Hu J, Zheng H, Yao Y, Paik J. Stem Cell Reports. 2018 Apr 10;10(4):1208-1221. doi: 10.1016/j.stemcr.2018.02.013. Epub 2018 Mar 29. PubMed
Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes. Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL. J Clin Invest. 2018 Jul 2;128(7):3008-3023. doi: 10.1172/JCI95231. Epub 2018 Jun 11. PubMed
Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J. Cell. 2018 Apr 19;173(3):677-692.e20. doi: 10.1016/j.cell.2018.03.002. PubMed
Metabolic regulation of transcription through compartmentalized NAD(+) biosynthesis. Ryu KW, Nandu T, Kim J, Challa S, DeBerardinis RJ, Kraus WL. Science. 2018 May 11;360(6389). pii: 360/6389/eaan5780. doi: 10.1126/science.aan5780. PubMed
A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene. Santo EE, Paik J. Gene. 2018 Oct 5;673:95-101. doi: 10.1016/j.gene.2018.06.048. Epub 2018 Jun 18. PubMed
An in vivo model for thyroid regeneration and folliculogenesis. Iwadate M, Takizawa Y, Shirai YT, Kimura S. Lab Invest. 2018 Sep;98(9):1126-1132. doi: 10.1038/s41374-018-0068-x. Epub 2018 Jun 26. PubMed
Homeobox oncogene activation by pan-cancer DNA hypermethylation. Su J, Huang YH, Cui X, Wang X, Zhang X, Lei Y, Xu J, Lin X, Chen K, Lv J, Goodell MA, Li W. Genome Biol. 2018 Aug 10;19(1):108. doi: 10.1186/s13059-018-1492-3. PubMed

Associated Plasmids

Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification. Trisno SL, Philo KED, McCracken KW, Cata EM, Ruiz-Torres S, Rankin SA, Han L, Nasr T, Chaturvedi P, Rothenberg ME, Mandegar MA, Wells SI, Zorn AM, Wells JM. Cell Stem Cell. 2018 Oct 4;23(4):501-515.e7. doi: 10.1016/j.stem.2018.08.008. Epub 2018 Sep 20. PubMed
PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia. Aries IM, Bodaar K, Karim SA, Chonghaile TN, Hinze L, Burns MA, Pfirrmann M, Degar J, Landrigan JT, Balbach S, Peirs S, Menten B, Isenhart R, Stevenson KE, Neuberg DS, Devidas M, Loh ML, Hunger SP, Teachey DT, Rabin KR, Winter SS, Dunsmore KP, Wood BL, Silverman LB, Sallan SE, Van Vlierberghe P, Orkin SH, Knoechel B, Letai AG, Gutierrez A. J Exp Med. 2018 Nov 7. pii: jem.20180570. doi: 10.1084/jem.20180570. PubMed

Associated Plasmids

Peptide-based PET quantifies target engagement of PD-L1 therapeutics. Kumar D, Lisok A, Dahmane E, McCoy M, Shelake S, Chatterjee S, Allaj V, Sysa-Shah P, Wharram B, Lesniak WG, Tully E, Gabrielson E, Jaffee EM, Poirier JT, Rudin CM, Gobburu JV, Pomper MG, Nimmagadda S. J Clin Invest. 2019 Feb 1;129(2):616-630. doi: 10.1172/JCI122216. Epub 2019 Jan 7. PubMed
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis. Santana-Codina N, Roeth AA, Zhang Y, Yang A, Mashadova O, Asara JM, Wang X, Bronson RT, Lyssiotis CA, Ying H, Kimmelman AC. Nat Commun. 2018 Nov 23;9(1):4945. doi: 10.1038/s41467-018-07472-8. PubMed
MED28 and forkhead box M1 (FOXM1) mediate matrix metalloproteinase 2 (MMP2)-dependent cellular migration in human nonsmall cell lung cancer (NSCLC) cells. Hsieh NT, Huang CY, Li CC, Wang IC, Lee MF. J Cell Physiol. 2019 Jul;234(7):11265-11275. doi: 10.1002/jcp.27784. Epub 2018 Nov 29. PubMed
Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. Zhang H, Savage S, Schultz AR, Bottomly D, White L, Segerdell E, Wilmot B, McWeeney SK, Eide CA, Nechiporuk T, Carlos A, Henson R, Lin C, Searles R, Ho H, Lam YL, Sweat R, Follit C, Jain V, Lind E, Borthakur G, Garcia-Manero G, Ravandi F, Kantarjian HM, Cortes J, Collins R, Buelow DR, Baker SD, Druker BJ, Tyner JW. Nat Commun. 2019 Jan 16;10(1):244. doi: 10.1038/s41467-018-08263-x. PubMed
A Code of Mono-phosphorylation Modulates the Function of RB. Sanidas I, Morris R, Fella KA, Rumde PH, Boukhali M, Tai EC, Ting DT, Lawrence MS, Haas W, Dyson NJ. Mol Cell. 2019 Mar 7;73(5):985-1000.e6. doi: 10.1016/j.molcel.2019.01.004. Epub 2019 Jan 30. PubMed
The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development. Kumar N, Tsai YH, Chen L, Zhou A, Banerjee KK, Saxena M, Huang S, Toke NH, Xing J, Shivdasani RA, Spence JR, Verzi MP. Development. 2019 Mar 1;146(5). pii: dev.172189. doi: 10.1242/dev.172189. PubMed
FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer. Arceci A, Bonacci T, Wang X, Stewart K, Damrauer JS, Hoadley KA, Emanuele MJ. Cell Rep. 2019 Mar 12;26(11):3076-3086.e6. doi: 10.1016/j.celrep.2019.02.054. PubMed
Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells. Yost KE, Clatterbuck Soper SF, Walker RL, Pineda MA, Zhu YJ, Ester CD, Showman S, Roschke AV, Waterfall JJ, Meltzer PS. Sci Rep. 2019 Mar 14;9(1):4544. doi: 10.1038/s41598-019-41058-8. PubMed
SWI/SNF-Compromised Cancers Are Susceptible to Bromodomain Inhibitors. Shorstova T, Marques M, Su J, Johnston J, Kleinman CL, Hamel N, Huang S, Alaoui-Jamali MA, Foulkes WD, Witcher M. Cancer Res. 2019 May 15;79(10):2761-2774. doi: 10.1158/0008-5472.CAN-18-1545. Epub 2019 Mar 15. PubMed
Inhibition of MYC by the SMARCB1 tumor suppressor. Weissmiller AM, Wang J, Lorey SL, Howard GC, Martinez E, Liu Q, Tansey WP. Nat Commun. 2019 May 1;10(1):2014. doi: 10.1038/s41467-019-10022-5. PubMed
A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development. Zhang X, McGrath PS, Salomone J, Rahal M, McCauley HA, Schweitzer J, Kovall R, Gebelein B, Wells JM. Dev Cell. 2019 Aug 5;50(3):367-380.e7. doi: 10.1016/j.devcel.2019.05.017. Epub 2019 Jun 6. PubMed
Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport. Moissoglu K, Yasuda K, Wang T, Chrisafis G, Mili S. Elife. 2019 Jul 10;8. pii: 44752. doi: 10.7554/eLife.44752. PubMed
Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21. Kim DS, Camacho CV, Nagari A, Malladi VS, Challa S, Kraus WL. Mol Cell. 2019 Sep 19;75(6):1270-1285.e14. doi: 10.1016/j.molcel.2019.06.020. Epub 2019 Jul 24. PubMed
BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Debruyne DN, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, Huang H, Moreau L, McLane M, Day DS, Marco E, Chen T, Gray NS, Wong KK, Orkin SH, Yuan GC, Young RA, George RE. Nature. 2019 Aug;572(7771):676-680. doi: 10.1038/s41586-019-1472-0. Epub 2019 Aug 7. PubMed
Mechanical Stabilization of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex. Zhang Q, Narayanan V, Mui KL, O'Bryan CS, Anderson RH, Kc B, Cabe JI, Denis KB, Antoku S, Roux KJ, Dickinson RB, Angelini TE, Gundersen GG, Conway DE, Lele TP. Curr Biol. 2019 Aug 2. pii: S0960-9822(19)30866-8. doi: 10.1016/j.cub.2019.07.021. PubMed

Associated Plasmids

The transferrin receptor CD71 regulates type II CD38, revealing tight topological compartmentalization of intracellular cyclic ADP-ribose production. Deng QW, Zhang J, Li T, He WM, Fang L, Lee HC, Zhao YJ. J Biol Chem. 2019 Oct 18;294(42):15293-15303. doi: 10.1074/jbc.RA119.010010. Epub 2019 Aug 21. PubMed
Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses. Timofeev O, Klimovich B, Schneikert J, Wanzel M, Pavlakis E, Noll J, Mutlu S, Elmshauser S, Nist A, Mernberger M, Lamp B, Wenig U, Brobeil A, Gattenlohner S, Kohler K, Stiewe T. EMBO J. 2019 Oct 15;38(20):e102096. doi: 10.15252/embj.2019102096. Epub 2019 Sep 4. PubMed
MUC1-C Activates the NuRD Complex to Drive Dedifferentiation of Triple-Negative Breast Cancer Cells. Hata T, Rajabi H, Takahashi H, Yasumizu Y, Li W, Jin C, Long MD, Hu Q, Liu S, Fushimi A, Yamashita N, Kui L, Hong D, Yamamoto M, Miyo M, Hiraki M, Maeda T, Suzuki Y, Samur MK, Kufe D. Cancer Res. 2019 Nov 15;79(22):5711-5722. doi: 10.1158/0008-5472.CAN-19-1034. Epub 2019 Sep 13. PubMed
Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16(INK4A). Gobl C, Morris VK, van Dam L, Visscher M, Polderman PE, Hartlmuller C, de Ruiter H, Hora M, Liesinger L, Birner-Gruenberger R, Vos HR, Reif B, Madl T, Dansen TB. Redox Biol. 2020 Jan;28:101316. doi: 10.1016/j.redox.2019.101316. Epub 2019 Sep 3. PubMed
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massague J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed
Spliceosomal disruption of the non-canonical BAF complex in cancer. Inoue D, Chew GL, Liu B, Michel BC, Pangallo J, D'Avino AR, Hitchman T, North K, Lee SC, Bitner L, Block A, Moore AR, Yoshimi A, Escobar-Hoyos L, Cho H, Penson A, Lu SX, Taylor J, Chen Y, Kadoch C, Abdel-Wahab O, Bradley RK. Nature. 2019 Oct;574(7778):432-436. doi: 10.1038/s41586-019-1646-9. Epub 2019 Oct 9. PubMed
MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. Freyre CAC, Rauher PC, Ejsing CS, Klemm RW. Mol Cell. 2019 Dec 5;76(5):811-825.e14. doi: 10.1016/j.molcel.2019.09.011. Epub 2019 Oct 15. PubMed
Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Xu M, Qin J, Wang L, Lee HJ, Kao CY, Liu D, Songyang Z, Chen J, Tsai MJ, Tsai SY. Sci Adv. 2019 Oct 9;5(10):eaax6366. doi: 10.1126/sciadv.aax6366. eCollection 2019 Oct. PubMed
Activation of G-Protein Coupled Receptor-Galphai Signaling Increases Keratinocyte Proliferation and Reduces Differentiation, Leading to Epidermal Hyperplasia. Pedro MP, Salinas Parra N, Gutkind JS, Iglesias-Bartolome R. J Invest Dermatol. 2020 Jun;140(6):1195-1203.e3. doi: 10.1016/j.jid.2019.10.012. Epub 2019 Nov 7. PubMed
Characterization of 3D Printed Stretching Devices for Imaging Force Transmission in Live-Cells. Mayer CR, Arsenovic PT, Bathula K, Denis KB, Conway DE. Cell Mol Bioeng. 2019 Jul 11;12(4):289-300. doi: 10.1007/s12195-019-00579-y. eCollection 2019 Aug. PubMed

Associated Plasmids

Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition. Xue JY, Zhao Y, Aronowitz J, Mai TT, Vides A, Qeriqi B, Kim D, Li C, de Stanchina E, Mazutis L, Risso D, Lito P. Nature. 2020 Jan;577(7790):421-425. doi: 10.1038/s41586-019-1884-x. Epub 2020 Jan 8. PubMed
Threonine Phosphorylation of IkappaBzeta Mediates Inhibition of Selective Proinflammatory Target Genes. Grondona P, Bucher P, Schmitt A, Schonfeld C, Streibl B, Muller A, Essmann F, Liberatori S, Mohammed S, Hennig A, Kramer D, Schulze-Osthoff K, Hailfinger S. J Invest Dermatol. 2020 Sep;140(9):1805-1814.e6. doi: 10.1016/j.jid.2019.12.036. Epub 2020 Feb 6. PubMed
Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response. Jabalee J, Towle R, Lawson J, Dickman C, Garnis C. Oncotarget. 2020 Feb 4;11(5):523-534. doi: 10.18632/oncotarget.27458. eCollection 2020 Feb 4. PubMed
BORIS/CTCFL promotes a switch from a proliferative towards an invasive phenotype in melanoma cells. Janssen SM, Moscona R, Elchebly M, Papadakis AI, Redpath M, Wang H, Rubin E, van Kempen LC, Spatz A. Cell Death Discov. 2020 Jan 2;6:1. doi: 10.1038/s41420-019-0235-x. eCollection 2020. PubMed
CIC is a critical regulator of neuronal differentiation. Hwang I, Pan H, Yao J, Elemento O, Zheng H, Paik J. JCI Insight. 2020 May 7;5(9). pii: 135826. doi: 10.1172/jci.insight.135826. PubMed
Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer. Parrilla A, Barber M, Majem B, Castellvi J, Morote J, Sanchez JL, Perez-Benavente A, Segura MF, Gil-Moreno A, Santamaria A. Cancers (Basel). 2020 Apr 6;12(4). pii: cancers12040886. doi: 10.3390/cancers12040886. PubMed
Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer. Parker SJ, Amendola CR, Hollinshead KER, Yu Q, Yamamoto K, Encarnacion-Rosado J, Rose RE, LaRue MM, Sohn ASW, Biancur DE, Paulo JA, Gygi SP, Jones DR, Wang H, Philips MR, Bar-Sagi D, Mancias JD, Kimmelman AC. Cancer Discov. 2020 Apr 27. pii: 2159-8290.CD-19-0959. doi: 10.1158/2159-8290.CD-19-0959. PubMed

Associated Plasmids

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC. Nature. 2020 May;581(7806):100-105. doi: 10.1038/s41586-020-2229-5. Epub 2020 Apr 22. PubMed

Associated Plasmids

A novel Cre-enabled tetracycline-inducible transgenic system for tissue-specific cytokine expression in the zebrafish: CETI-PIC3. Ibrahim S, Harris-Kawano A, Haider I, Mirmira RG, Sims EK, Anderson RM. Dis Model Mech. 2020 Jun 26;13(6). pii: dmm.042556. doi: 10.1242/dmm.042556. PubMed
The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint. Manohar S, Yu Q, Gygi SP, King RW. Mol Cell Proteomics. 2020 Jun 18. pii: RA120.002069. doi: 10.1074/mcp.RA120.002069. PubMed
The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D. J Clin Invest. 2020 Jul 23. pii: 134217. doi: 10.1172/JCI134217. PubMed
Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. Huang D, Camacho CV, Setlem R, Ryu KW, Parameswaran B, Gupta RK, Kraus WL. Mol Cell. 2020 Sep 17;79(6):934-949.e14. doi: 10.1016/j.molcel.2020.08.002. Epub 2020 Aug 20. PubMed
RNA localization and co-translational interactions control RAB13 GTPase function and cell migration. Moissoglu K, Stueland M, Gasparski AN, Wang T, Jenkins LM, Hastings ML, Mili S. EMBO J. 2020 Nov 2;39(21):e104958. doi: 10.15252/embj.2020104958. Epub 2020 Sep 18. PubMed
Mutant SF3B1 promotes AKT- and NF-kappaB-driven mammary tumorigenesis. Liu B, Liu Z, Chen S, Ki M, Erickson C, Reis-Filho JS, Durham BH, Chang Q, de Stanchina E, Sun Y, Rabadan R, Abdel-Wahab O, Chandarlapaty S. J Clin Invest. 2021 Jan 4;131(1). pii: 138315. doi: 10.1172/JCI138315. PubMed
Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Maitituoheti M, Keung EZ, Tang M, Yan L, Alam H, Han G, Singh AK, Raman AT, Terranova C, Sarkar S, Orouji E, Amin SB, Sharma S, Williams M, Samant NS, Dhamdhere M, Zheng N, Shah T, Shah A, Axelrad JB, Anvar NE, Lin YH, Jiang S, Chang EQ, Ingram DR, Wang WL, Lazar A, Lee MG, Muller F, Wang L, Ying H, Rai K. Cell Rep. 2020 Oct 20;33(3):108293. doi: 10.1016/j.celrep.2020.108293. PubMed
Increased demand for NAD(+) relative to ATP drives aerobic glycolysis. Luengo A, Li Z, Gui DY, Sullivan LB, Zagorulya M, Do BT, Ferreira R, Naamati A, Ali A, Lewis CA, Thomas CJ, Spranger S, Matheson NJ, Vander Heiden MG. Mol Cell. 2021 Feb 18;81(4):691-707.e6. doi: 10.1016/j.molcel.2020.12.012. Epub 2020 Dec 30. PubMed
Phosphorylation of PKCdelta by FER tips the balance from EGFR degradation to recycling. Lonic A, Gehling F, Belle L, Li X, Schieber NL, Nguyen EV, Goodall GJ, Parton RG, Daly RJ, Khew-Goodall Y. J Cell Biol. 2021 Feb 1;220(2). pii: 211661. doi: 10.1083/jcb.201902073. PubMed
Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry. Niekamp P, Guzman G, Leier HC, Rashidfarrokhi A, Richina V, Pott F, Barisch C, Holthuis JCM, Tafesse FG. mBio. 2021 Jan 26;12(1). pii: mBio.03141-20. doi: 10.1128/mBio.03141-20. PubMed
Creb5 establishes the competence for Prg4 expression in articular cartilage. Zhang CH, Gao Y, Jadhav U, Hung HH, Holton KM, Grodzinsky AJ, Shivdasani RA, Lassar AB. Commun Biol. 2021 Mar 12;4(1):332. doi: 10.1038/s42003-021-01857-0. PubMed
Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks. Schilling EM, Scherer M, Rothemund F, Stamminger T. PLoS Pathog. 2021 Mar 26;17(3):e1009460. doi: 10.1371/journal.ppat.1009460. eCollection 2021 Mar. PubMed
The Transmembrane Mucin MUC1 Facilitates beta1-Integrin-Mediated Bacterial Invasion. Li X, Wubbolts RW, Bleumink-Pluym NMC, van Putten JPM, Strijbis K. mBio. 2021 Apr 6;12(2). pii: mBio.03491-20. doi: 10.1128/mBio.03491-20. PubMed
SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, Guo JY, Pine S, Van Remmen H, Li H, White E, Liu C, Kiledjian M, Pestov DG, Steven Zheng XF. Nat Commun. 2021 Apr 15;12(1):2259. doi: 10.1038/s41467-021-22480-x. PubMed
Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis. Zhang S, Yuan B, Lam JH, Zhou J, Zhou X, Ramos-Mandujano G, Tian X, Liu Y, Han R, Li Y, Gao X, Li M, Yang M. Cell Discov. 2021 May 4;7(1):30. doi: 10.1038/s41421-021-00259-0. PubMed
RNA transcripts stimulate homologous recombination by forming DR-loops. Ouyang J, Yadav T, Zhang JM, Yang H, Rheinbay E, Guo H, Haber DA, Lan L, Zou L. Nature. 2021 Jun;594(7862):283-288. doi: 10.1038/s41586-021-03538-8. Epub 2021 May 12. PubMed
Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Sharif H, Hollingsworth LR, Griswold AR, Hsiao JC, Wang Q, Bachovchin DA, Wu H. Immunity. 2021 Jul 13;54(7):1392-1404.e10. doi: 10.1016/j.immuni.2021.04.024. Epub 2021 May 20. PubMed

Associated Plasmids

The histone demethylase PHF8 regulates astrocyte differentiation and function. Iacobucci S, Padilla N, Gabrielli M, Navarro C, Lombardi M, Vicioso-Mantis M, Verderio C, de la Cruz X, Martinez-Balbas MA. Development. 2021 Jun 15;148(12). pii: 268981. doi: 10.1242/dev.194951. Epub 2021 Jun 28. PubMed
Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer. Inoue Y, Nikolic A, Farnsworth D, Shi R, Johnson FD, Liu A, Ladanyi M, Somwar R, Gallo M, Lockwood WW. Elife. 2021 Jun 14;10. pii: 66524. doi: 10.7554/eLife.66524. PubMed
Oxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation. Perryman A, Speen AM, Kim HH, Hoffman JR, Clapp PW, Rivera Martin W, Snouwaert JN, Koller BH, Porter NA, Jaspers I. Am J Respir Cell Mol Biol. 2021 Nov;65(5):500-512. doi: 10.1165/rcmb.2021-0032OC. PubMed
Nuclear ADP-ribosylation drives IFNgamma-dependent STAT1alpha enhancer formation in macrophages. Gupte R, Nandu T, Kraus WL. Nat Commun. 2021 Jun 24;12(1):3931. doi: 10.1038/s41467-021-24225-2. PubMed
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir. Zhang SM, Rehling D, Jemth AS, Throup A, Landazuri N, Almlof I, Gottmann M, Valerie NCK, Borhade SR, Wakchaure P, Page BDG, Desroses M, Homan EJ, Scobie M, Rudd SG, Berglund UW, Soderberg-Naucler C, Stenmark P, Helleday T. Cell Chem Biol. 2021 Jun 22. pii: S2451-9456(21)00268-3. doi: 10.1016/j.chembiol.2021.06.001. PubMed
Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2. Tang M, Pei G, Su D, Wang C, Feng X, Srivastava M, Chen Z, Zhao Z, Chen J. Nucleic Acids Res. 2021 Jul 21;49(13):7476-7491. doi: 10.1093/nar/gkab540. PubMed
Acidic pH irreversibly activates the signaling enzyme SARM1. Zhao YJ, He WM, Zhao ZY, Li WH, Wang QW, Hou YN, Tan Y, Zhang D. FEBS J. 2021 Jul 2. doi: 10.1111/febs.16104. PubMed
beta-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs. Ibrahim S, Johnson M, Stephens CH, Xu J, Moore R, Mariani A, Contreras C, Syed F, Mirmira RG, Anderson RM, Sims EK. Mol Metab. 2021 Jul 9;53:101289. doi: 10.1016/j.molmet.2021.101289. PubMed
Telomere dysfunction instigates inflammation in inflammatory bowel disease. Chakravarti D, Lee R, Multani AS, Santoni A, Keith Z, Hsu WH, Chang K, Reyes L, Rashid A, Wu CJ, Li J, Zhang J, Shim HS, Chandra K, Deng P, Spring DJ, Nielsen OH, Riis LB, Mayigegowda KK, Blutt SE, Zhang J, Younes M, DuPont A, Thirumurthi S, Vilar E, Estes MK, Colla S, Shroyer NF, DePinho RA. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29). pii: 2024853118. doi: 10.1073/pnas.2024853118. PubMed
Cytomegalovirus immediate-early 1 proteins form a structurally distinct protein class with adaptations determining cross-species barriers. Schweininger J, Scherer M, Rothemund F, Schilling EM, Worz S, Stamminger T, Muller YA. PLoS Pathog. 2021 Aug 9;17(8):e1009863. doi: 10.1371/journal.ppat.1009863. eCollection 2021 Aug. PubMed
UTX condensation underlies its tumour-suppressive activity. Shi B, Li W, Song Y, Wang Z, Ju R, Ulman A, Hu J, Palomba F, Zhao Y, Le JP, Jarrard W, Dimoff D, Digman MA, Gratton E, Zang C, Jiang H. Nature. 2021 Sep;597(7878):726-731. doi: 10.1038/s41586-021-03903-7. Epub 2021 Sep 15. PubMed
Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice. Rauschendorfer T, Gurri S, Heggli I, Maddaluno L, Meyer M, Ingles-Prieto A, Janovjak H, Werner S. Life Sci Alliance. 2021 Sep 21;4(11). pii: 4/11/e202101100. doi: 10.26508/lsa.202101100. Print 2021 Nov. PubMed
IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay. Akaki K, Ogata K, Yamauchi Y, Iwai N, Tse KM, Hia F, Mochizuki A, Ishihama Y, Mino T, Takeuchi O. Elife. 2021 Oct 12;10. pii: 71966. doi: 10.7554/eLife.71966. PubMed
dupe-Mapping the genetic landscape of DNA double-strand break repair. Hussmann JA, Ling J, Ravisankar P, Yan J, Cirincione A, Xu A, Simpson D, Yang D, Bothmer A, Cotta-Ramusino C, Weissman JS, Adamson B. Cell PubMed
p53 Forms Redox-Dependent Protein-Protein Interactions through Cysteine 277. Shi T, Polderman PE, Pages-Gallego M, van Es RM, Vos HR, Burgering BMT, Dansen TB. Antioxidants (Basel). 2021 Oct 6;10(10). pii: antiox10101578. doi: 10.3390/antiox10101578. PubMed
Diverse alterations associated with resistance to KRAS(G12C) inhibition. Zhao Y, Murciano-Goroff YR, Xue JY, Ang A, Lucas J, Mai TT, Da Cruz Paula AF, Saiki AY, Mohn D, Achanta P, Sisk AE, Arora KS, Roy RS, Kim D, Li C, Lim LP, Li M, Bahr A, Loomis BR, de Stanchina E, Reis-Filho JS, Weigelt B, Berger M, Riely G, Arbour KC, Lipford JR, Li BT, Lito P. Nature. 2021 Nov;599(7886):679-683. doi: 10.1038/s41586-021-04065-2. Epub 2021 Nov 10. PubMed
HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway. Smith AE, Ferraro E, Safonov A, Morales CB, Lahuerta EJA, Li Q, Kulick A, Ross D, Solit DB, de Stanchina E, Reis-Filho J, Rosen N, Arribas J, Razavi P, Chandarlapaty S. Nat Commun. 2021 Nov 18;12(1):6667. doi: 10.1038/s41467-021-27093-y. PubMed
The consequences of differential origin licensing dynamics in distinct chromatin environments. Mei L, Kedziora KM, Song EA, Purvis JE, Cook JG. Nucleic Acids Res. 2022 Sep 23;50(17):9601-9620. doi: 10.1093/nar/gkac003. PubMed
Quantitative profiling of adaptation to cyclin E overproduction. Limas JC, Littlejohn AN, House AM, Kedziora KM, Mouery BL, Ma B, Fleifel D, Walens A, Aleman MM, Dominguez D, Cook JG. Life Sci Alliance. 2022 Feb 16;5(5):e202201378. doi: 10.26508/lsa.202201378. Print 2022 May. PubMed
Differential requirements for different subfamilies of the mammalian SWI/SNF chromatin remodeling enzymes in myoblast cell cycle progression and expression of the Pax7 regulator. Padilla-Benavides T, Olea-Flores M, Nshanji Y, Maung MT, Syed SA, Imbalzano AN. Biochim Biophys Acta Gene Regul Mech. 2022 Feb;1865(2):194801. doi: 10.1016/j.bbagrm.2022.194801. Epub 2022 Feb 23. PubMed
Ca(2+)-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair. Niekamp P, Scharte F, Sokoya T, Vittadello L, Kim Y, Deng Y, Sudhoff E, Hilderink A, Imlau M, Clarke CJ, Hensel M, Burd CG, Holthuis JCM. Nat Commun. 2022 Apr 6;13(1):1875. doi: 10.1038/s41467-022-29481-4. PubMed
Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism. Chong YK, Tartey S, Yoshikawa Y, Imami K, Li S, Yoshinaga M, Hirabayashi A, Liu G, Vandenbon A, Hia F, Uehata T, Mino T, Suzuki Y, Noda T, Ferrandon D, Standley DM, Ishihama Y, Takeuchi O. Sci Signal. 2022 Apr 12;15(729):eabm5011. doi: 10.1126/scisignal.abm5011. Epub 2022 Apr 12. PubMed
The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation. Ladewig E, Michelini F, Jhaveri K, Castel P, Carmona J, Fairchild L, Zuniga AG, Arruabarrena-Aristorena A, Cocco E, Blawski R, Kittane S, Zhang Y, Sallaku M, Baldino L, Hristidis V, Chandarlapaty S, Abdel-Wahab O, Leslie C, Scaltriti M, Toska E. Cancer Res. 2022 Jun 15;82(12):2269-2280. doi: 10.1158/0008-5472.CAN-22-0446. PubMed
Targeting MUC1-C Suppresses Chronic Activation of Cytosolic Nucleotide Receptors and STING in Triple-Negative Breast Cancer. Yamashita N, Fushimi A, Morimoto Y, Bhattacharya A, Hagiwara M, Yamamoto M, Hata T, Shapiro GI, Long MD, Liu S, Kufe D. Cancers (Basel). 2022 May 24;14(11). pii: cancers14112580. doi: 10.3390/cancers14112580. PubMed
Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment. Morimoto Y, Fushimi A, Yamashita N, Hagiwara M, Bhattacharya A, Cheng J, Frost TC, Ahmad R, Daimon T, Huang L, Hata T, Takahashi H, Yamamoto M, Suzuki Y, DeCaprio JA, Kufe D. Oncogene. 2022 Jul;41(27):3511-3523. doi: 10.1038/s41388-022-02361-3. Epub 2022 Jun 10. PubMed
TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors. Wang W, Chandra A, Goldman N, Yoon S, Ferrari EK, Nguyen SC, Joyce EF, Vahedi G. Nat Immunol. 2022 Jul;23(7):1052-1062. doi: 10.1038/s41590-022-01232-z. Epub 2022 Jun 20. PubMed
Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1. Mabe NW, Huang M, Dalton GN, Alexe G, Schaefer DA, Geraghty AC, Robichaud AL, Conway AS, Khalid D, Mader MM, Belk JA, Ross KN, Sheffer M, Linde MH, Ly N, Yao W, Rotiroti MC, Smith BAH, Wernig M, Bertozzi CR, Monje M, Mitsiades CS, Majeti R, Satpathy AT, Stegmaier K, Majzner RG. Nat Cancer. 2022 Aug;3(8):976-993. doi: 10.1038/s43018-022-00405-x. Epub 2022 Jul 11. PubMed
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma. Dorado Garcia H, Pusch F, Bei Y, von Stebut J, Ibanez G, Guillan K, Imami K, Gurgen D, Rolff J, Helmsauer K, Meyer-Liesener S, Timme N, Bardinet V, Chamorro Gonzalez R, MacArthur IC, Chen CY, Schulz J, Wengner AM, Furth C, Lala B, Eggert A, Seifert G, Hundsoerfer P, Kirchner M, Mertins P, Selbach M, Lissat A, Dubois F, Horst D, Schulte JH, Spuler S, You D, Dela Cruz F, Kung AL, Haase K, DiVirgilio M, Scheer M, Ortiz MV, Henssen AG. Nat Commun. 2022 Jul 25;13(1):4297. doi: 10.1038/s41467-022-32023-7. PubMed
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway. Sokoya T, Parolek J, Foged MM, Danylchuk DI, Bozan M, Sarkar B, Hilderink A, Philippi M, Botto LD, Terhal PA, Makitie O, Piehler J, Kim Y, Burd CG, Klymchenko AS, Maeda K, Holthuis JCM. Elife. 2022 Sep 14;11:e79278. doi: 10.7554/eLife.79278. PubMed
Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes. Sengupta S, Das S, Crespo AC, Cornel AM, Patel AG, Mahadevan NR, Campisi M, Ali AK, Sharma B, Rowe JH, Huang H, Debruyne DN, Cerda ED, Krajewska M, Dries R, Chen M, Zhang S, Soriano L, Cohen MA, Versteeg R, Jaenisch R, Spranger S, Romee R, Miller BC, Barbie DA, Nierkens S, Dyer MA, Lieberman J, George RE. Nat Cancer. 2022 Oct;3(10):1228-1246. doi: 10.1038/s43018-022-00427-5. Epub 2022 Sep 22. PubMed
Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition. Ogden S, Carys K, Ahmed I, Bruce J, Sharrocks AD. Oncogene. 2022 Oct;41(43):4808-4822. doi: 10.1038/s41388-022-02465-w. Epub 2022 Sep 24. PubMed
Non-enzymatic role of SOD1 in intestinal stem cell growth. Wang YC, Leng XX, Zhou CB, Lu SY, Tsang CK, Xu J, Zhang MM, Chen HM, Fang JY. Cell Death Dis. 2022 Oct 20;13(10):882. doi: 10.1038/s41419-022-05267-w. PubMed
The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma. Bauer J, Kohler N, Maringer Y, Bucher P, Bilich T, Zwick M, Dicks S, Nelde A, Dubbelaar M, Scheid J, Wacker M, Heitmann JS, Schroeder S, Rieth J, Denk M, Richter M, Klein R, Bonzheim I, Luibrand J, Holzer U, Ebinger M, Brecht IB, Bitzer M, Boerries M, Feucht J, Salih HR, Rammensee HG, Hailfinger S, Walz JS. Nat Commun. 2022 Oct 27;13(1):6401. doi: 10.1038/s41467-022-33746-3. PubMed
The N(6)-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity. Yoshinaga M, Han K, Morgens DW, Horii T, Kobayashi R, Tsuruyama T, Hia F, Yasukura S, Kajiya A, Cai T, Cruz PHC, Vandenbon A, Suzuki Y, Kawahara Y, Hatada I, Bassik MC, Takeuchi O. Nat Commun. 2022 Oct 28;13(1):6435. doi: 10.1038/s41467-022-34078-y. PubMed
The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate. Li Z, Fang F, Long Y, Zhao Q, Wang X, Ye Z, Meng T, Gu X, Xiang W, Xiong C, Li H. Cell Biosci. 2022 Nov 4;12(1):181. doi: 10.1186/s13578-022-00917-0. PubMed
Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells. McBrearty N, Cho C, Chen J, Zahedi F, Peck AR, Radaelli E, Assenmacher CA, Pavlak C, Devine A, Yu P, Lu Z, Zhang H, Li J, Pitarresi JR, Astsaturov I, Cukierman E, Rustgi AK, Stanger BZ, Rui H, Fuchs SY. Mol Cancer Res. 2023 Mar 1;21(3):228-239. doi: 10.1158/1541-7786.MCR-22-0602. PubMed
Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism. Romitti M, Tourneur A, de Faria da Fonseca B, Doumont G, Gillotay P, Liao XH, Eski SE, Van Simaeys G, Chomette L, Lasolle H, Monestier O, Kasprzyk DF, Detours V, Singh SP, Goldman S, Refetoff S, Costagliola S. Nat Commun. 2022 Nov 17;13(1):7057. doi: 10.1038/s41467-022-34776-7. PubMed
MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression. Farnsworth DA, Inoue Y, Johnson FD, de Rappard-Yuswack G, Lu D, Shi R, Ma LIJ, Mattar MS, Somwar R, Ladanyi M, Unni AM, Lockwood WW. NPJ Precis Oncol. 2022 Nov 23;6(1):88. doi: 10.1038/s41698-022-00328-x. PubMed
Creb5 coordinates synovial joint formation with the genesis of articular cartilage. Zhang CH, Gao Y, Hung HH, Zhuo Z, Grodzinsky AJ, Lassar AB. Nat Commun. 2022 Nov 26;13(1):7295. doi: 10.1038/s41467-022-35010-0. PubMed
A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Hou YN, Cai Y, Li WH, He WM, Zhao ZY, Zhu WJ, Wang Q, Mai X, Liu J, Lee HC, Stjepanovic G, Zhang H, Zhao YJ. Nat Commun. 2022 Dec 22;13(1):7898. doi: 10.1038/s41467-022-35581-y. PubMed
Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function. Nitschke L, Hu RC, Miller AN, Lucas L, Cooper TA. Nucleic Acids Res. 2023 Feb 22;51(3):1245-1259. doi: 10.1093/nar/gkac1219. PubMed
The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma. Lu DY, Ellegast JM, Ross KN, Malone CF, Lin S, Mabe NW, Dharia NV, Meyer A, Conway A, Su AH, Selich-Anderson J, Taslim C, Byrum AK, Seong BKA, Adane B, Gray NS, Rivera MN, Lessnick SL, Stegmaier K. Nat Cell Biol. 2023 Feb;25(2):285-297. doi: 10.1038/s41556-022-01059-8. Epub 2023 Jan 19. PubMed
Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer. Dhital B, Santasusagna S, Kirthika P, Xu M, Li P, Carceles-Cordon M, Soni RK, Li Z, Hendrickson RC, Schiewer MJ, Kelly WK, Sternberg CN, Luo J, Lujambio A, Cordon-Cardo C, Alvarez-Fernandez M, Malumbres M, Huang H, Ertel A, Domingo-Domenech J, Rodriguez-Bravo V. Cell Rep Med. 2023 Feb 21;4(2):100937. doi: 10.1016/j.xcrm.2023.100937. Epub 2023 Feb 13. PubMed
Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells. Hart ML, Quon E, Vigil ABG, Engstrom IA, Newsom OJ, Davidsen K, Hoellerbauer P, Carlisle SM, Sullivan LB. Elife. 2023 Mar 8;12:e78654. doi: 10.7554/eLife.78654. PubMed
Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer. Chen WY, Thuy Dung PV, Yeh HL, Chen WH, Jiang KC, Li HR, Chen ZQ, Hsiao M, Huang J, Wen YC, Liu YN. Redox Biol. 2023 Jun;62:102686. doi: 10.1016/j.redox.2023.102686. Epub 2023 Mar 21. PubMed
mRNA Location and Translation Rate Determine Protein Targeting to Dual Destinations. Gasparski AN, Moissoglu K, Pallikkuth S, Meydan S, Guydosh NR, Mili S. bioRxiv. 2023 Apr 26:2023.04.24.538105. doi: 10.1101/2023.04.24.538105. Preprint. PubMed
SMARCB1 regulates the hypoxic stress response in sickle cell trait. Soeung M, Perelli L, Chen Z, Dondossola E, Ho IL, Carbone F, Zhang L, Khan H, Le CN, Zhu C, Peoples MD, Feng N, Jiang S, Zacharias NM, Minelli R, Shapiro DD, Deem AK, Gao S, Cheng EH, Lucchetti D, Walker CL, Carugo A, Giuliani V, Heffernan TP, Viale A, Tannir NM, Draetta GF, Msaouel P, Genovese G. Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2209639120. doi: 10.1073/pnas.2209639120. Epub 2023 May 15. PubMed
A GPCR screening in human keratinocytes identifies that the metabolite receptor HCAR3 controls epithelial proliferation, migration, and cellular respiration. Pedro MP, Lund K, Kang SWS, Chen T, Stuelten CH, Porat-Shliom N, Iglesias-Bartolome R. bioRxiv [Preprint]. 2023 May 31:2023.05.30.542853. doi: 10.1101/2023.05.30.542853. PubMed
NRF1 promotes primordial germ cell development, proliferation and survival. Wang P, Su J, Wang J, Xie Y, Chen W, Zhong J, Wang Y. Cell Prolif. 2024 Jan;57(1):e13533. doi: 10.1111/cpr.13533. Epub 2023 Aug 4. PubMed
Serine protease 35 regulates the fibroblast matrisome in response to hyperosmotic stress. Sanger CS, Cernakova M, Wietecha MS, Garau Paganella L, Labouesse C, Dudaryeva OY, Roubaty C, Stumpe M, Mazza E, Tibbitt MW, Dengjel J, Werner S. Sci Adv. 2023 Sep;9(35):eadh9219. doi: 10.1126/sciadv.adh9219. Epub 2023 Aug 30. PubMed
RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells. Krishnan R, Lapierre M, Gautreau B, Nixon KCJ, El Ghamrasni S, Patel PS, Hao J, Yerlici VT, Guturi KKN, St-Germain J, Mateo F, Saad A, Algouneh A, Earnshaw R, Shili D, Seitova A, Miller J, Khosraviani N, Penn A, Ho B, Sanchez O, Hande MP, Masson JY, Brown GW, Alaoui-Jamali M, Reynolds JJ, Arrowsmith C, Raught B, Pujana MA, Mekhail K, Stewart GS, Hakem A, Hakem R. Nucleic Acids Res. 2023 Oct 27;51(19):10484-10505. doi: 10.1093/nar/gkad733. PubMed
The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP. Korner M, Meyer SR, Marincola G, Kern MJ, Grimm C, Schuelein-Voelk C, Fischer U, Hofmann K, Buchberger A. Elife. 2023 Sep 15;12:e92409. doi: 10.7554/eLife.92409. PubMed
MUC1-C intersects chronic inflammation with epigenetic reprogramming by regulating the set1a compass complex in cancer progression. Bhattacharya A, Fushimi A, Wang K, Yamashita N, Morimoto Y, Ishikawa S, Daimon T, Liu T, Liu S, Long MD, Kufe D. Commun Biol. 2023 Oct 11;6(1):1030. doi: 10.1038/s42003-023-05395-9. PubMed
Tau accumulation in degradative organelles is associated to lysosomal stress. Piovesana E, Magrin C, Ciccaldo M, Sola M, Bellotto M, Molinari M, Papin S, Paganetti P. Sci Rep. 2023 Oct 21;13(1):18024. doi: 10.1038/s41598-023-44979-7. PubMed
A PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Ovarian Cancer Cells. Challa S, Nandu T, Kim HB, Gong A, Renshaw CW, Li WC, Tan X, Camacho CV, Chen J, Kraus WL. bioRxiv [Preprint]. 2023 Oct 14:2023.10.13.562273. doi: 10.1101/2023.10.13.562273. PubMed
Lactate activates the mitochondrial electron transport chain independently of its metabolism. Cai X, Ng CP, Jones O, Fung TS, Ryu KW, Li D, Thompson CB. Mol Cell. 2023 Nov 2;83(21):3904-3920.e7. doi: 10.1016/j.molcel.2023.09.034. Epub 2023 Oct 24. PubMed
Divergent Roles of KLF4 During Primordial Germ Cell Fate Induction from Human Embryonic Stem Cells. Fang F, Li Z, Zhang X, Huang Q, Lu S, Wang X. Reprod Sci. 2024 Mar;31(3):727-735. doi: 10.1007/s43032-023-01360-3. Epub 2023 Oct 26. PubMed
Inactivation of Tumor Suppressor CYLD Inhibits Fibroblast Reprogramming to Pluripotency. Bekas N, Samiotaki M, Papathanasiou M, Mokos P, Pseftogas A, Xanthopoulos K, Thanos D, Mosialos G, Dafou D. Cancers (Basel). 2023 Oct 15;15(20):4997. doi: 10.3390/cancers15204997. PubMed
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells. Yamashita N, Withers H, Morimoto Y, Bhattacharya A, Haratake N, Daimon T, Fushimi A, Nakashoji A, Thorner AR, Isenhart E, Rosario S, Long MD, Kufe D. iScience. 2023 Oct 11;26(11):108168. doi: 10.1016/j.isci.2023.108168. eCollection 2023 Nov 17. PubMed
Chikungunya virus nonstructural protein 1 is a versatile RNA capping and decapping enzyme. Law MCY, Zhang K, Tan YB, Nguyen TM, Luo D. J Biol Chem. 2023 Dec;299(12):105415. doi: 10.1016/j.jbc.2023.105415. Epub 2023 Oct 31. PubMed
APC/C prevents non-canonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor-induced arrest. Mouery BL, Baker EM, Mills CA, Herring LE, Fleifel D, Cook JG. bioRxiv [Preprint]. 2023 Nov 9:2023.11.09.566394. doi: 10.1101/2023.11.09.566394. PubMed
ESRP1 controls biogenesis and function of a large abundant multiexon circRNA. Liu D, Dredge BK, Bert AG, Pillman KA, Toubia J, Guo W, Dyakov BJA, Migault MM, Conn VM, Conn SJ, Gregory PA, Gingras AC, Patel D, Wu B, Goodall GJ. Nucleic Acids Res. 2024 Feb 9;52(3):1387-1403. doi: 10.1093/nar/gkad1138. PubMed
Quaking isoforms cooperate to promote the mesenchymal phenotype. Neumann DP, Phillips CA, Lumb R, Palethorpe HM, Ramani Y, Hollier BG, Selth LA, Bracken CP, Goodall GJ, Gregory PA. Mol Biol Cell. 2024 Feb 1;35(2):ar17. doi: 10.1091/mbc.E23-08-0316. Epub 2023 Nov 29. PubMed
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