pInducer20 Citations (154)
Originally described in: The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo.Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3665-70. doi: 10.1073/pnas.1019736108. Epub 2011 Feb 9. PubMed Journal
Articles Citing pInducer20
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Coordinated regulation of autophagy and apoptosis determines endothelial cell fate during Dengue virus type 2 infection. Huang J, Li Y, Qi Y, Zhang Y, Zhang L, Wang Z, Zhang X, Gui L. Mol Cell Biochem. 2014 Dec;397(1-2):157-65. doi: 10.1007/s11010-014-2183-3. Epub 2014 Aug 20. PubMed |
FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1). Kloet DE, Polderman PE, Eijkelenboom A, Smits LM, van Triest MH, van den Berg MC, Groot Koerkamp MJ, van Leenen D, Lijnzaad P, Holstege FC, Burgering BM. Biochem J. 2015 Jul 15;469(2):289-98. doi: 10.1042/BJ20140831. Epub 2015 May 20. PubMed |
Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells. Kawprasertsri S, Pietras RJ, Marquez-Garban DC, Boonyaratanakornkit V. Cancer Lett. 2016 May 1;374(2):279-91. doi: 10.1016/j.canlet.2016.02.014. Epub 2016 Feb 15. PubMed |
At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells. Rozovski U, Harris DM, Li P, Liu Z, Wu JY, Grgurevic S, Faderl S, Ferrajoli A, Wierda WG, Martinez M, Verstovsek S, Keating MJ, Estrov Z. J Immunol. 2016 May 15;196(10):4400-9. doi: 10.4049/jimmunol.1402108. Epub 2016 Apr 13. PubMed |
Transformation by Polyomavirus Middle T Antigen Involves A Unique Bimodal Interaction with the Hippo Effector YAP. Rouleau C, Pores Fernando AT, Hwang JH, Faure N, Jiang T, White EA, Roberts TM, Schaffhausen BS. J Virol. 2016 May 18. pii: JVI.00417-16. PubMed |
A PPARgamma-Bnip3 axis couples adipose mitochondrial fusion-fission balance to systemic insulin sensitivity. Tol MJ, Ottenhoff R, van Eijk M, Zelcer N, Aten J, Houten SM, Geerts D, van Roomen C, Bierlaagh MC, Scheij S, Hoeksema MA, Aerts JM, Bogan JS, Dorn GW 2nd, Argmann CA, Verhoeven AJ. Diabetes. 2016 Jun 20. pii: db160243. PubMed |
Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures.
Kesarwani AK, Ramirez O, Gupta AK, Yang X, Murthy T, Minella AC, Pillai MM.
Oncogene. 2016 Aug 15. doi: 10.1038/onc.2016.279.
PubMed
Associated Plasmids |
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Eshtad S, Mavajian Z, Rudd SG, Visnes T, Bostrom J, Altun M, Helleday T. Oncogenesis. 2016 Dec 5;5(12):e275. doi: 10.1038/oncsis.2016.72. PubMed |
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.
Adamson B, Norman TM, Jost M, Cho MY, Nunez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS.
Cell. 2016 Dec 15;167(7):1867-1882.e21. doi: 10.1016/j.cell.2016.11.048.
PubMed
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Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. Liau BB, Sievers C, Donohue LK, Gillespie SM, Flavahan WA, Miller TE, Venteicher AS, Hebert CH, Carey CD, Rodig SJ, Shareef SJ, Najm FJ, van Galen P, Wakimoto H, Cahill DP, Rich JN, Aster JC, Suva ML, Patel AP, Bernstein BE. Cell Stem Cell. 2016 Dec 2. pii: S1934-5909(16)30399-X. doi: 10.1016/j.stem.2016.11.003. PubMed |
Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas. Piunti A, Hashizume R, Morgan MA, Bartom ET, Horbinski CM, Marshall SA, Rendleman EJ, Ma Q, Takahashi YH, Woodfin AR, Misharin AV, Abshiru NA, Lulla RR, Saratsis AM, Kelleher NL, James CD, Shilatifard A. Nat Med. 2017 Apr;23(4):493-500. doi: 10.1038/nm.4296. Epub 2017 Feb 27. PubMed |
Prmt1-mediated translation regulation is a crucial vulnerability of cancer. Hsu JH, Hubbell-Engler B, Adelmant G, Huang J, Joyce CE, Vazquez F, Weir BA, Montgomery P, Tsherniak A, Giacomelli AO, Perry JA, Trowbridge J, Fujiwara Y, Cowley GS, Xie H, Kim W, Novina CD, Hahn WC, Marto JA, Orkin SH. Cancer Res. 2017 Jun 27. pii: canres.0216.2017. doi: 10.1158/0008-5472.CAN-17-0216. PubMed |
Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma. Britton E, Rogerson C, Mehta S, Li Y, Li X, Fitzgerald RC, Ang YS, Sharrocks AD. PLoS Genet. 2017 Aug 31;13(8):e1006879. doi: 10.1371/journal.pgen.1006879. eCollection 2017 Aug. PubMed |
A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. Slemmons KK, Crose LES, Riedel S, Sushnitha M, Belyea B, Linardic CM. Mol Cancer Res. 2017 Dec;15(12):1777-1791. doi: 10.1158/1541-7786.MCR-17-0004. Epub 2017 Sep 18. PubMed |
Rapid DNA replication origin licensing protects stem cell pluripotency.
Matson JP, Dumitru R, Coryell P, Baxley RM, Chen W, Twaroski K, Webber BR, Tolar J, Bielinsky AK, Purvis JE, Cook JG.
Elife. 2017 Nov 17;6. doi: 10.7554/eLife.30473.
PubMed
Associated Plasmids |
FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression. Hornsveld M, Smits LMM, Meerlo M, van Amersfoort M, Groot Koerkamp MJA, van Leenen D, Kloet DEA, Holstege FCP, Derksen PWB, Burgering BMT, Dansen TB. Cancer Res. 2018 May 1;78(9):2356-2369. doi: 10.1158/0008-5472.CAN-17-2511. Epub 2018 Feb 12. PubMed |
Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors. Hwang I, Cao D, Na Y, Kim DY, Zhang T, Yao J, Oh H, Hu J, Zheng H, Yao Y, Paik J. Stem Cell Reports. 2018 Apr 10;10(4):1208-1221. doi: 10.1016/j.stemcr.2018.02.013. Epub 2018 Mar 29. PubMed |
Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes. Rodriguez-Muela N, Parkhitko A, Grass T, Gibbs RM, Norabuena EM, Perrimon N, Singh R, Rubin LL. J Clin Invest. 2018 Jul 2;128(7):3008-3023. doi: 10.1172/JCI95231. Epub 2018 Jun 11. PubMed |
Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J. Cell. 2018 Apr 19;173(3):677-692.e20. doi: 10.1016/j.cell.2018.03.002. PubMed |
Metabolic regulation of transcription through compartmentalized NAD(+) biosynthesis. Ryu KW, Nandu T, Kim J, Challa S, DeBerardinis RJ, Kraus WL. Science. 2018 May 11;360(6389). pii: 360/6389/eaan5780. doi: 10.1126/science.aan5780. PubMed |
A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene. Santo EE, Paik J. Gene. 2018 Oct 5;673:95-101. doi: 10.1016/j.gene.2018.06.048. Epub 2018 Jun 18. PubMed |
An in vivo model for thyroid regeneration and folliculogenesis. Iwadate M, Takizawa Y, Shirai YT, Kimura S. Lab Invest. 2018 Sep;98(9):1126-1132. doi: 10.1038/s41374-018-0068-x. Epub 2018 Jun 26. PubMed |
Homeobox oncogene activation by pan-cancer DNA hypermethylation.
Su J, Huang YH, Cui X, Wang X, Zhang X, Lei Y, Xu J, Lin X, Chen K, Lv J, Goodell MA, Li W.
Genome Biol. 2018 Aug 10;19(1):108. doi: 10.1186/s13059-018-1492-3.
PubMed
Associated Plasmids |
Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification. Trisno SL, Philo KED, McCracken KW, Cata EM, Ruiz-Torres S, Rankin SA, Han L, Nasr T, Chaturvedi P, Rothenberg ME, Mandegar MA, Wells SI, Zorn AM, Wells JM. Cell Stem Cell. 2018 Oct 4;23(4):501-515.e7. doi: 10.1016/j.stem.2018.08.008. Epub 2018 Sep 20. PubMed |
PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia.
Aries IM, Bodaar K, Karim SA, Chonghaile TN, Hinze L, Burns MA, Pfirrmann M, Degar J, Landrigan JT, Balbach S, Peirs S, Menten B, Isenhart R, Stevenson KE, Neuberg DS, Devidas M, Loh ML, Hunger SP, Teachey DT, Rabin KR, Winter SS, Dunsmore KP, Wood BL, Silverman LB, Sallan SE, Van Vlierberghe P, Orkin SH, Knoechel B, Letai AG, Gutierrez A.
J Exp Med. 2018 Nov 7. pii: jem.20180570. doi: 10.1084/jem.20180570.
PubMed
Associated Plasmids |
Peptide-based PET quantifies target engagement of PD-L1 therapeutics. Kumar D, Lisok A, Dahmane E, McCoy M, Shelake S, Chatterjee S, Allaj V, Sysa-Shah P, Wharram B, Lesniak WG, Tully E, Gabrielson E, Jaffee EM, Poirier JT, Rudin CM, Gobburu JV, Pomper MG, Nimmagadda S. J Clin Invest. 2019 Feb 1;129(2):616-630. doi: 10.1172/JCI122216. Epub 2019 Jan 7. PubMed |
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis. Santana-Codina N, Roeth AA, Zhang Y, Yang A, Mashadova O, Asara JM, Wang X, Bronson RT, Lyssiotis CA, Ying H, Kimmelman AC. Nat Commun. 2018 Nov 23;9(1):4945. doi: 10.1038/s41467-018-07472-8. PubMed |
MED28 and forkhead box M1 (FOXM1) mediate matrix metalloproteinase 2 (MMP2)-dependent cellular migration in human nonsmall cell lung cancer (NSCLC) cells. Hsieh NT, Huang CY, Li CC, Wang IC, Lee MF. J Cell Physiol. 2019 Jul;234(7):11265-11275. doi: 10.1002/jcp.27784. Epub 2018 Nov 29. PubMed |
Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. Zhang H, Savage S, Schultz AR, Bottomly D, White L, Segerdell E, Wilmot B, McWeeney SK, Eide CA, Nechiporuk T, Carlos A, Henson R, Lin C, Searles R, Ho H, Lam YL, Sweat R, Follit C, Jain V, Lind E, Borthakur G, Garcia-Manero G, Ravandi F, Kantarjian HM, Cortes J, Collins R, Buelow DR, Baker SD, Druker BJ, Tyner JW. Nat Commun. 2019 Jan 16;10(1):244. doi: 10.1038/s41467-018-08263-x. PubMed |
A Code of Mono-phosphorylation Modulates the Function of RB. Sanidas I, Morris R, Fella KA, Rumde PH, Boukhali M, Tai EC, Ting DT, Lawrence MS, Haas W, Dyson NJ. Mol Cell. 2019 Mar 7;73(5):985-1000.e6. doi: 10.1016/j.molcel.2019.01.004. Epub 2019 Jan 30. PubMed |
The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development. Kumar N, Tsai YH, Chen L, Zhou A, Banerjee KK, Saxena M, Huang S, Toke NH, Xing J, Shivdasani RA, Spence JR, Verzi MP. Development. 2019 Mar 1;146(5). pii: dev.172189. doi: 10.1242/dev.172189. PubMed |
FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer. Arceci A, Bonacci T, Wang X, Stewart K, Damrauer JS, Hoadley KA, Emanuele MJ. Cell Rep. 2019 Mar 12;26(11):3076-3086.e6. doi: 10.1016/j.celrep.2019.02.054. PubMed |
Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells. Yost KE, Clatterbuck Soper SF, Walker RL, Pineda MA, Zhu YJ, Ester CD, Showman S, Roschke AV, Waterfall JJ, Meltzer PS. Sci Rep. 2019 Mar 14;9(1):4544. doi: 10.1038/s41598-019-41058-8. PubMed |
SWI/SNF-Compromised Cancers Are Susceptible to Bromodomain Inhibitors. Shorstova T, Marques M, Su J, Johnston J, Kleinman CL, Hamel N, Huang S, Alaoui-Jamali MA, Foulkes WD, Witcher M. Cancer Res. 2019 May 15;79(10):2761-2774. doi: 10.1158/0008-5472.CAN-18-1545. Epub 2019 Mar 15. PubMed |
Inhibition of MYC by the SMARCB1 tumor suppressor. Weissmiller AM, Wang J, Lorey SL, Howard GC, Martinez E, Liu Q, Tansey WP. Nat Commun. 2019 May 1;10(1):2014. doi: 10.1038/s41467-019-10022-5. PubMed |
A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development. Zhang X, McGrath PS, Salomone J, Rahal M, McCauley HA, Schweitzer J, Kovall R, Gebelein B, Wells JM. Dev Cell. 2019 Aug 5;50(3):367-380.e7. doi: 10.1016/j.devcel.2019.05.017. Epub 2019 Jun 6. PubMed |
Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport. Moissoglu K, Yasuda K, Wang T, Chrisafis G, Mili S. Elife. 2019 Jul 10;8. pii: 44752. doi: 10.7554/eLife.44752. PubMed |
Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21. Kim DS, Camacho CV, Nagari A, Malladi VS, Challa S, Kraus WL. Mol Cell. 2019 Sep 19;75(6):1270-1285.e14. doi: 10.1016/j.molcel.2019.06.020. Epub 2019 Jul 24. PubMed |
BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Debruyne DN, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, Huang H, Moreau L, McLane M, Day DS, Marco E, Chen T, Gray NS, Wong KK, Orkin SH, Yuan GC, Young RA, George RE. Nature. 2019 Aug;572(7771):676-680. doi: 10.1038/s41586-019-1472-0. Epub 2019 Aug 7. PubMed |
Mechanical Stabilization of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex.
Zhang Q, Narayanan V, Mui KL, O'Bryan CS, Anderson RH, Kc B, Cabe JI, Denis KB, Antoku S, Roux KJ, Dickinson RB, Angelini TE, Gundersen GG, Conway DE, Lele TP.
Curr Biol. 2019 Aug 2. pii: S0960-9822(19)30866-8. doi: 10.1016/j.cub.2019.07.021.
PubMed
Associated Plasmids |
The transferrin receptor CD71 regulates type II CD38, revealing tight topological compartmentalization of intracellular cyclic ADP-ribose production. Deng QW, Zhang J, Li T, He WM, Fang L, Lee HC, Zhao YJ. J Biol Chem. 2019 Oct 18;294(42):15293-15303. doi: 10.1074/jbc.RA119.010010. Epub 2019 Aug 21. PubMed |
Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses. Timofeev O, Klimovich B, Schneikert J, Wanzel M, Pavlakis E, Noll J, Mutlu S, Elmshauser S, Nist A, Mernberger M, Lamp B, Wenig U, Brobeil A, Gattenlohner S, Kohler K, Stiewe T. EMBO J. 2019 Oct 15;38(20):e102096. doi: 10.15252/embj.2019102096. Epub 2019 Sep 4. PubMed |
MUC1-C Activates the NuRD Complex to Drive Dedifferentiation of Triple-Negative Breast Cancer Cells. Hata T, Rajabi H, Takahashi H, Yasumizu Y, Li W, Jin C, Long MD, Hu Q, Liu S, Fushimi A, Yamashita N, Kui L, Hong D, Yamamoto M, Miyo M, Hiraki M, Maeda T, Suzuki Y, Samur MK, Kufe D. Cancer Res. 2019 Nov 15;79(22):5711-5722. doi: 10.1158/0008-5472.CAN-19-1034. Epub 2019 Sep 13. PubMed |
Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16(INK4A). Gobl C, Morris VK, van Dam L, Visscher M, Polderman PE, Hartlmuller C, de Ruiter H, Hora M, Liesinger L, Birner-Gruenberger R, Vos HR, Reif B, Madl T, Dansen TB. Redox Biol. 2020 Jan;28:101316. doi: 10.1016/j.redox.2019.101316. Epub 2019 Sep 3. PubMed |
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massague J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed |
Spliceosomal disruption of the non-canonical BAF complex in cancer. Inoue D, Chew GL, Liu B, Michel BC, Pangallo J, D'Avino AR, Hitchman T, North K, Lee SC, Bitner L, Block A, Moore AR, Yoshimi A, Escobar-Hoyos L, Cho H, Penson A, Lu SX, Taylor J, Chen Y, Kadoch C, Abdel-Wahab O, Bradley RK. Nature. 2019 Oct;574(7778):432-436. doi: 10.1038/s41586-019-1646-9. Epub 2019 Oct 9. PubMed |
MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. Freyre CAC, Rauher PC, Ejsing CS, Klemm RW. Mol Cell. 2019 Dec 5;76(5):811-825.e14. doi: 10.1016/j.molcel.2019.09.011. Epub 2019 Oct 15. PubMed |
Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Xu M, Qin J, Wang L, Lee HJ, Kao CY, Liu D, Songyang Z, Chen J, Tsai MJ, Tsai SY. Sci Adv. 2019 Oct 9;5(10):eaax6366. doi: 10.1126/sciadv.aax6366. eCollection 2019 Oct. PubMed |
Activation of G-Protein Coupled Receptor-Galphai Signaling Increases Keratinocyte Proliferation and Reduces Differentiation, Leading to Epidermal Hyperplasia. Pedro MP, Salinas Parra N, Gutkind JS, Iglesias-Bartolome R. J Invest Dermatol. 2020 Jun;140(6):1195-1203.e3. doi: 10.1016/j.jid.2019.10.012. Epub 2019 Nov 7. PubMed |
Characterization of 3D Printed Stretching Devices for Imaging Force Transmission in Live-Cells.
Mayer CR, Arsenovic PT, Bathula K, Denis KB, Conway DE.
Cell Mol Bioeng. 2019 Jul 11;12(4):289-300. doi: 10.1007/s12195-019-00579-y. eCollection 2019 Aug.
PubMed
Associated Plasmids |
Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition. Xue JY, Zhao Y, Aronowitz J, Mai TT, Vides A, Qeriqi B, Kim D, Li C, de Stanchina E, Mazutis L, Risso D, Lito P. Nature. 2020 Jan;577(7790):421-425. doi: 10.1038/s41586-019-1884-x. Epub 2020 Jan 8. PubMed |
Threonine Phosphorylation of IkappaBzeta Mediates Inhibition of Selective Proinflammatory Target Genes. Grondona P, Bucher P, Schmitt A, Schonfeld C, Streibl B, Muller A, Essmann F, Liberatori S, Mohammed S, Hennig A, Kramer D, Schulze-Osthoff K, Hailfinger S. J Invest Dermatol. 2020 Sep;140(9):1805-1814.e6. doi: 10.1016/j.jid.2019.12.036. Epub 2020 Feb 6. PubMed |
Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response. Jabalee J, Towle R, Lawson J, Dickman C, Garnis C. Oncotarget. 2020 Feb 4;11(5):523-534. doi: 10.18632/oncotarget.27458. eCollection 2020 Feb 4. PubMed |
BORIS/CTCFL promotes a switch from a proliferative towards an invasive phenotype in melanoma cells. Janssen SM, Moscona R, Elchebly M, Papadakis AI, Redpath M, Wang H, Rubin E, van Kempen LC, Spatz A. Cell Death Discov. 2020 Jan 2;6:1. doi: 10.1038/s41420-019-0235-x. eCollection 2020. PubMed |
CIC is a critical regulator of neuronal differentiation. Hwang I, Pan H, Yao J, Elemento O, Zheng H, Paik J. JCI Insight. 2020 May 7;5(9). pii: 135826. doi: 10.1172/jci.insight.135826. PubMed |
Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer. Parrilla A, Barber M, Majem B, Castellvi J, Morote J, Sanchez JL, Perez-Benavente A, Segura MF, Gil-Moreno A, Santamaria A. Cancers (Basel). 2020 Apr 6;12(4). pii: cancers12040886. doi: 10.3390/cancers12040886. PubMed |
Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer.
Parker SJ, Amendola CR, Hollinshead KER, Yu Q, Yamamoto K, Encarnacion-Rosado J, Rose RE, LaRue MM, Sohn ASW, Biancur DE, Paulo JA, Gygi SP, Jones DR, Wang H, Philips MR, Bar-Sagi D, Mancias JD, Kimmelman AC.
Cancer Discov. 2020 Apr 27. pii: 2159-8290.CD-19-0959. doi: 10.1158/2159-8290.CD-19-0959.
PubMed
Associated Plasmids |
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I.
Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC.
Nature. 2020 May;581(7806):100-105. doi: 10.1038/s41586-020-2229-5. Epub 2020 Apr 22.
PubMed
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A novel Cre-enabled tetracycline-inducible transgenic system for tissue-specific cytokine expression in the zebrafish: CETI-PIC3. Ibrahim S, Harris-Kawano A, Haider I, Mirmira RG, Sims EK, Anderson RM. Dis Model Mech. 2020 Jun 26;13(6). pii: dmm.042556. doi: 10.1242/dmm.042556. PubMed |
The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint. Manohar S, Yu Q, Gygi SP, King RW. Mol Cell Proteomics. 2020 Jun 18. pii: RA120.002069. doi: 10.1074/mcp.RA120.002069. PubMed |
The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D. J Clin Invest. 2020 Jul 23. pii: 134217. doi: 10.1172/JCI134217. PubMed |
Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. Huang D, Camacho CV, Setlem R, Ryu KW, Parameswaran B, Gupta RK, Kraus WL. Mol Cell. 2020 Sep 17;79(6):934-949.e14. doi: 10.1016/j.molcel.2020.08.002. Epub 2020 Aug 20. PubMed |
RNA localization and co-translational interactions control RAB13 GTPase function and cell migration. Moissoglu K, Stueland M, Gasparski AN, Wang T, Jenkins LM, Hastings ML, Mili S. EMBO J. 2020 Nov 2;39(21):e104958. doi: 10.15252/embj.2020104958. Epub 2020 Sep 18. PubMed |
Mutant SF3B1 promotes AKT- and NF-kappaB-driven mammary tumorigenesis. Liu B, Liu Z, Chen S, Ki M, Erickson C, Reis-Filho JS, Durham BH, Chang Q, de Stanchina E, Sun Y, Rabadan R, Abdel-Wahab O, Chandarlapaty S. J Clin Invest. 2021 Jan 4;131(1). pii: 138315. doi: 10.1172/JCI138315. PubMed |
Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Maitituoheti M, Keung EZ, Tang M, Yan L, Alam H, Han G, Singh AK, Raman AT, Terranova C, Sarkar S, Orouji E, Amin SB, Sharma S, Williams M, Samant NS, Dhamdhere M, Zheng N, Shah T, Shah A, Axelrad JB, Anvar NE, Lin YH, Jiang S, Chang EQ, Ingram DR, Wang WL, Lazar A, Lee MG, Muller F, Wang L, Ying H, Rai K. Cell Rep. 2020 Oct 20;33(3):108293. doi: 10.1016/j.celrep.2020.108293. PubMed |
Increased demand for NAD(+) relative to ATP drives aerobic glycolysis. Luengo A, Li Z, Gui DY, Sullivan LB, Zagorulya M, Do BT, Ferreira R, Naamati A, Ali A, Lewis CA, Thomas CJ, Spranger S, Matheson NJ, Vander Heiden MG. Mol Cell. 2021 Feb 18;81(4):691-707.e6. doi: 10.1016/j.molcel.2020.12.012. Epub 2020 Dec 30. PubMed |
Phosphorylation of PKCdelta by FER tips the balance from EGFR degradation to recycling. Lonic A, Gehling F, Belle L, Li X, Schieber NL, Nguyen EV, Goodall GJ, Parton RG, Daly RJ, Khew-Goodall Y. J Cell Biol. 2021 Feb 1;220(2). pii: 211661. doi: 10.1083/jcb.201902073. PubMed |
Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry. Niekamp P, Guzman G, Leier HC, Rashidfarrokhi A, Richina V, Pott F, Barisch C, Holthuis JCM, Tafesse FG. mBio. 2021 Jan 26;12(1). pii: mBio.03141-20. doi: 10.1128/mBio.03141-20. PubMed |
Creb5 establishes the competence for Prg4 expression in articular cartilage. Zhang CH, Gao Y, Jadhav U, Hung HH, Holton KM, Grodzinsky AJ, Shivdasani RA, Lassar AB. Commun Biol. 2021 Mar 12;4(1):332. doi: 10.1038/s42003-021-01857-0. PubMed |
Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks. Schilling EM, Scherer M, Rothemund F, Stamminger T. PLoS Pathog. 2021 Mar 26;17(3):e1009460. doi: 10.1371/journal.ppat.1009460. eCollection 2021 Mar. PubMed |
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